Inhibition of Glucose Utilization in Isolated Rat Soleus Muscle by Pseudouridine: Implications for Renal Failure

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Abstract

Pseudouridine (ψ) is an outstanding nucleoside which is not rebuilt into the tRNA once the parent tRNA is broken down, ψ inhibits basal glucose utilization in isolated rat soleus muscle with intact membrane with AD<sub>50</sub> 42 μmol/l and C<sub>max</sub> 66%. ψ at concentrations found in renal failure patients inhibits both the insulin-and tolbutamide-stimulated glucose utilization. Its inhibitory activity is partially additive with diltiazem inhibition and nonadditive in the case of magnesium depletion. It is concluded that ψ inhibits glucose utilization at the level of Ca modulation in the insulin regulatory cascade.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1993

Publication date (Print): 1993

Publication date (Electronic): 12 December 2008

Volume: 65

Issue: 1

Pages: 108-110

Affiliations

Institute of Preventive and Clinical Medicine, Bratislava, Czechoslovakia

Article

Publisher ID: 187450 Other ID: Nephron 1993;65:108–110

DOI: 10.1159/000187450

PubMed ID: 8413768

SO-VID: af6509cc-7988-4600-beee-6ffbfcead311

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 06 November 1992

Page count

Pages: 3

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