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      Inhibition of Glucose Utilization in Isolated Rat Soleus Muscle by Pseudouridine: Implications for Renal Failure

      , ,

      Nephron

      S. Karger AG

      Glucose utilization, Pseudouridine, Renal failure, Soleus muscle, Tolbutamide, Mg deficiency, Insulin

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          Abstract

          Pseudouridine (ψ) is an outstanding nucleoside which is not rebuilt into the tRNA once the parent tRNA is broken down, ψ inhibits basal glucose utilization in isolated rat soleus muscle with intact membrane with AD<sub>50</sub> 42 μmol/l and C<sub>max</sub> 66%. ψ at concentrations found in renal failure patients inhibits both the insulin-and tolbutamide-stimulated glucose utilization. Its inhibitory activity is partially additive with diltiazem inhibition and nonadditive in the case of magnesium depletion. It is concluded that ψ inhibits glucose utilization at the level of Ca modulation in the insulin regulatory cascade.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1993
          1993
          12 December 2008
          : 65
          : 1
          : 108-110
          Affiliations
          Institute of Preventive and Clinical Medicine, Bratislava, Czechoslovakia
          Article
          187450 Nephron 1993;65:108–110
          10.1159/000187450
          8413768
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 3
          Categories
          Original Paper

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