There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The effect of cocaine (7.5, 15 and 30 mg/kg) administered in acute or subchronic mode,
on the mating behaviour of sexually active male rats varied in a dose- and mode-dependent
manner. Regardless of mode of treatment, 30 mg/kg markedly impaired the rats copulatory
ability and impairment continued for a week after suspension of subchronic treatment.
An acute dose of 15 mg/kg reduced intromission frequency, while in subchronic mode
it also reduced ejaculation latency. Mount frequency was increased by 7.5 and 15 mg/kg,
but only on first injection. In the case of sexually-naive male rats, acute administration
of cocaine (3-30 mg/kg) stimulated penile erections at 7.5 mg/kg and motor hyperactivity
at all doses. (-) Eticlopride (0.025 and 0.05 mg/kg), a DA D2 antagonist, counteracted
cocaine-induced motor hyperactivity but not penile erection, which it enhanced. (-)
Eticlopride at the same doses also antagonized cocaine potentiation of lisuride (0.2
mg/kg)-induced behavioural effects. When male rats treated with subchronic cocaine
(15 mg/kg) were injected with the DA D2 agonist SND 919 (0.1 mg/kg), they displayed
a more marked stretching-yawning behaviour than control animals receiving SND 919
at the same dose. The involvement of DA D2 receptors in cocaine-induced effects is
suggested.