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      Physician Confidence in Artificial Intelligence: An Online Mobile Survey

      research-article
      , MD 1 , , MD 2 , , MD 3 , , MD 1 , , MD 4 , , MD 1 ,
      (Reviewer), (Reviewer), (Reviewer)
      Journal of Medical Internet Research
      JMIR Publications
      artificial intelligence, AI, awareness, physicians

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          Abstract

          Background

          It is expected that artificial intelligence (AI) will be used extensively in the medical field in the future.

          Objective

          The purpose of this study is to investigate the awareness of AI among Korean doctors and to assess physicians’ attitudes toward the medical application of AI.

          Methods

          We conducted an online survey composed of 11 closed-ended questions using Google Forms. The survey consisted of questions regarding the recognition of and attitudes toward AI, the development direction of AI in medicine, and the possible risks of using AI in the medical field.

          Results

          A total of 669 participants completed the survey. Only 40 (5.9%) answered that they had good familiarity with AI. However, most participants considered AI useful in the medical field (558/669, 83.4% agreement). The advantage of using AI was seen as the ability to analyze vast amounts of high-quality, clinically relevant data in real time. Respondents agreed that the area of medicine in which AI would be most useful is disease diagnosis (558/669, 83.4% agreement). One possible problem cited by the participants was that AI would not be able to assist in unexpected situations owing to inadequate information (196/669, 29.3%). Less than half of the participants(294/669, 43.9%) agreed that AI is diagnostically superior to human doctors. Only 237 (35.4%) answered that they agreed that AI could replace them in their jobs.

          Conclusions

          This study suggests that Korean doctors and medical students have favorable attitudes toward AI in the medical field. The majority of physicians surveyed believed that AI will not replace their roles in the future.

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          Most cited references31

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          Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features

          Lung cancer is the most prevalent cancer worldwide, and histopathological assessment is indispensable for its diagnosis. However, human evaluation of pathology slides cannot accurately predict patients' prognoses. In this study, we obtain 2,186 haematoxylin and eosin stained histopathology whole-slide images of lung adenocarcinoma and squamous cell carcinoma patients from The Cancer Genome Atlas (TCGA), and 294 additional images from Stanford Tissue Microarray (TMA) Database. We extract 9,879 quantitative image features and use regularized machine-learning methods to select the top features and to distinguish shorter-term survivors from longer-term survivors with stage I adenocarcinoma (P<0.003) or squamous cell carcinoma (P=0.023) in the TCGA data set. We validate the survival prediction framework with the TMA cohort (P<0.036 for both tumour types). Our results suggest that automatically derived image features can predict the prognosis of lung cancer patients and thereby contribute to precision oncology. Our methods are extensible to histopathology images of other organs.
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            Adapting to Artificial Intelligence

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              Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer

              Tumors are characterized by somatic mutations that drive biological processes ultimately reflected in tumor phenotype. With regard to radiographic phenotypes, generally unconnected through present understanding to the presence of specific mutations, artificial intelligence (AI) methods can automatically quantify phenotypic characters by using predefined, engineered algorithms or automatic deep-learning methods, a process also known as radiomics. Here we demonstrate how imaging phenotypes can be connected to somatic mutations through an integrated analysis of independent datasets of 763 lung adenocarcinoma patients with somatic mutation testing and engineered computed tomography (CT) image analytics. We developed radiomic signatures capable of distinguishing between tumor genotypes in a discovery cohort (n=353) and verified them in an independent validation cohort (n=352). All radiomic signatures significantly outperformed conventional radiographic predictors (tumor volume and maximum diameter). We found a radiomic signature related to radiographic heterogeneity that successfuilly discriminated between EGFR+ and EGFR- cases (AUC=0.69). Combining this signature with a clinical model of EGFR status (AUC=0.70) significantly improved prediction accuracy (AUC=0.75). The highest performing signature was capable of distinguishing between EGFR+ and KRAS+ tumors (AUC=0.80) and, when combined with a clinical model (AUC=0.81), substantially improved its performance (AUC=0.86). A KRAS+/KRAS- radiomic signature also showed significant albeit lower performance (AUC=0.63) and did not improve accuracy of a clinical predictor of KRAS status. Our results argue that somatic mutations drive distinct radiographic phenotypes that can be predicted by radiomics. This work has implications for the use of imaging-based biomarkers in the clinic, as applied non-invasively, repeatedly and at low cost.
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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                J. Med. Internet Res
                JMIR
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                1439-4456
                1438-8871
                March 2019
                25 March 2019
                : 21
                : 3
                : e12422
                Affiliations
                [1 ] Division of Nephrology Department of Internal Medicine Soonchunhyang University Hospital Seoul Republic of Korea
                [2 ] Department of Urology Soonchunhyang University Hospital Seoul Republic of Korea
                [3 ] Department of Orthopedic Surgery Soonchunhyang University Seoul Hospital Seoul Republic of Korea
                [4 ] Department of Internal Medicine New York Medical College New York Health Hospital New York, NY United States
                Author notes
                Corresponding Author: Soon Hyo Kwon ksoonhyo@ 123456schmc.ac.kr
                Author information
                http://orcid.org/0000-0001-7432-0953
                http://orcid.org/0000-0002-4490-3610
                http://orcid.org/0000-0001-6263-6037
                http://orcid.org/0000-0002-3950-1641
                http://orcid.org/0000-0002-9952-8117
                http://orcid.org/0000-0002-4114-4196
                Article
                v21i3e12422
                10.2196/12422
                6452288
                30907742
                af721e57-842f-48d8-966b-a40916232ecb
                ©Songhee Oh, Jae Heon Kim, Sung-Woo Choi, Hee Jeong Lee, Jungrak Hong, Soon Hyo Kwon. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 25.03.2019.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/.as well as this copyright and license information must be included.

                History
                : 15 October 2018
                : 3 December 2018
                : 9 January 2019
                : 17 January 2019
                Categories
                Original Paper
                Original Paper

                Medicine
                artificial intelligence,ai,awareness,physicians
                Medicine
                artificial intelligence, ai, awareness, physicians

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