Inhibition des muskarinergen Kaliumionenstroms durch das neue Klasse-III-Antiarrhythmikum KB130015 im Vergleich zu Ibutilide Translated title: Inhibition of the Muscarinic Potassium Current by KB130015, a New Antiarrhythmic Agent to Treat Atrial Fibrillation
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Vagus-induced atrial fibrillation is of particular clinical interest. The muscarinic
potassium current I(K(ACh)) mediates the induction of vagus-induced atrial fibrillation.
Selective inhibition of I(K(ACh)) seems to be an option to treat atrial fibrillation.
The application of amiodarone, presently one of the most important antiarrhythmic
agents in the parmacological treatment of atrial fibrillation, is limited by its adverse
effects. KB130015, a new amiodarone derivative, and ibutilide are new class III antiarrhythmic