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      Inhibition des muskarinergen Kaliumionenstroms durch das neue Klasse-III-Antiarrhythmikum KB130015 im Vergleich zu Ibutilide Translated title: Inhibition of the Muscarinic Potassium Current by KB130015, a New Antiarrhythmic Agent to Treat Atrial Fibrillation

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      Medizinische Klinik

      Springer Nature America, Inc

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          Abstract

          Vagus-induced atrial fibrillation is of particular clinical interest. The muscarinic potassium current I(K(ACh)) mediates the induction of vagus-induced atrial fibrillation. Selective inhibition of I(K(ACh)) seems to be an option to treat atrial fibrillation. The application of amiodarone, presently one of the most important antiarrhythmic agents in the parmacological treatment of atrial fibrillation, is limited by its adverse effects. KB130015, a new amiodarone derivative, and ibutilide are new class III antiarrhythmic agents.

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          Author and article information

          Journal
          Medizinische Klinik
          Med Klin
          Springer Nature America, Inc
          0723-5003
          1615-6722
          November 2005
          November 2005
          : 100
          : 11
          : 697-703
          Article
          10.1007/s00063-005-1096-z
          16328176
          © 2005
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