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      Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.

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          Abstract

          Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological studies. Since vitamin D is also implicated in vascular protection and affects IGF-1 biology, we hypothesized that it would influence the effect of IGF-1 on IMT.

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          Author and article information

          Journal
          Atherosclerosis
          Atherosclerosis
          1879-1484
          0021-9150
          Oct 2014
          : 236
          : 2
          Affiliations
          [1 ] Department of Internal Medicine, AOU-IRCCS San Martino-IST, University of Genova, Genova, Italy. Electronic address: pietroameri@unige.it.
          [2 ] Department of Internal Medicine, AOU-IRCCS San Martino-IST, University of Genova, Genova, Italy; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
          [3 ] Department of Internal Medicine, AOU-IRCCS San Martino-IST, University of Genova, Genova, Italy.
          [4 ] Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA; Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands.
          [5 ] Department of Laboratory Medicine, AOU-IRCCS San Martino-IST, Genova, Italy.
          [6 ] Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, National Institute on Aging, NIH, Baltimore, MD, USA.
          [7 ] Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
          Article
          S0021-9150(14)01349-5 NIHMS716699
          10.1016/j.atherosclerosis.2014.08.022
          4642711
          25150940
          af7d1188-91e2-40d4-bda3-8ae21ec48c2f
          Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
          History

          Aging,Atherosclerosis,Endothelial,IGF-1,Intima-media thickness,Vitamin D

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