Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [ 11 C]DPA-713 PET

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Abstract

The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain’s resident immune cells, microglia. Here we used [ ¹¹C]DPA-713 and positron emission tomography to quantify the 18 kDa translocator protein, a marker of activated microglia or reactive astrocytes, in the brains of patients with post-treatment Lyme disease symptoms of any duration compared to healthy controls. Genotyping for the TSPO rs6971 polymorphism was completed, and individuals with the rare, low affinity binding genotype were excluded. Data from eight brain regions demonstrated higher [ ¹¹C]DPA-713 binding in 12 patients relative to 19 controls. [ ¹¹C]DPA-713 PET is a promising tool to study cerebral glial activation in PTLDS and its link to cognitive symptoms.

Electronic supplementary material

The online version of this article (10.1186/s12974-018-1381-4) contains supplementary material, which is available to authorized users.

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Lyme borreliosis

Allen Steere, Franc Strle, Gary Wormser … (2016)

Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia. Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3). However, the disease can present with any of these manifestations. During infection, the bacteria migrate through the host tissues, adhere to certain cells and can evade immune clearance. Yet, these organisms are eventually killed by both innate and adaptive immune responses and most inflammatory manifestations of the infection resolve. Except for patients with erythema migrans, Lyme borreliosis is diagnosed based on a characteristic clinical constellation of signs and symptoms with serological confirmation of infection. All manifestations of the infection can usually be treated with appropriate antibiotic regimens, but the disease can be followed by post-infectious sequelae in some patients. Prevention of Lyme borreliosis primarily involves the avoidance of tick bites by personal protective measures.

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Author and article information

Contributors

Jennifer M. Coughlin: jcoughl2@jhmi.edu

Ting Yang: tyang6@jhu.edu

Alison W. Rebman: arebman1@jhmi.edu

Kathleen T. Bechtold: kbechto1@jhmi.edu

Yong Du: duyong@jhu.edu

William B. Mathews: bmathews@jhu.edu

Wojciech G. Lesniak: wlesnia1@jhmi.edu

Erica A. Mihm: emihm1@jhmi.edu

Sarah M. Frey: sfrey6@jhmi.edu

Erica S. Marshall: emarsh15@jhmi.edu

Hailey B. Rosenthal: haileyrosenthal@gmail.com

Tristan A. Reekie: tristan.reekie@sydney.edu.au

Michael Kassiou: michael.kassiou@sydney.edu.au

Robert F. Dannals: rfd@jhu.edu

Mark J. Soloski: mski@jhmi.edu

John N. Aucott: (410) 616-7596 , jaucott2@jhmi.edu

Martin G. Pomper: 410-955-2789 , mpomper@jhmi.edu

Journal

Journal ID (nlm-ta): J Neuroinflammation

Journal ID (iso-abbrev): J Neuroinflammation

Title: Journal of Neuroinflammation

Publisher: BioMed Central (London )

ISSN (Electronic): 1742-2094

Publication date (Electronic): 19 December 2018

Publication date PMC-release: 19 December 2018

Publication date Collection: 2018

Volume: 15

Electronic Location Identifier: 346

Affiliations

[1 ]ISNI 0000 0001 2171 9311, GRID grid.21107.35, Department of Psychiatry and Behavioral Sciences, , Johns Hopkins University School of Medicine, ; Baltimore, MD USA

[2 ]ISNI 0000 0001 2171 9311, GRID grid.21107.35, Russell H. Morgan Department of Radiology and Radiological Science, , Johns Hopkins University School of Medicine, ; Baltimore, MD USA

[3 ]ISNI 0000 0001 2171 9311, GRID grid.21107.35, Division of Rheumatology, Department of Medicine, , Johns Hopkins University School of Medicine, ; Baltimore, MD USA

[4 ]ISNI 0000 0001 2171 9311, GRID grid.21107.35, Department of Physical Medicine and Rehabilitation, , Johns Hopkins University School of Medicine, ; Baltimore, MD USA

[5 ]ISNI 0000 0004 1936 834X, GRID grid.1013.3, School of Chemistry, , The University of Sydney, ; Sydney, NSW 2006 Australia

[6 ]Baltimore, USA

[7 ]Lutherville, USA

Article

Publisher ID: 1381

DOI: 10.1186/s12974-018-1381-4

PMC ID: 6299943

PubMed ID: 30567544

SO-VID: af890c82-3e61-4518-ae54-749b903bad50

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 30 July 2018

Date accepted : 27 November 2018

Funding

Funded by: FundRef http://dx.doi.org/10.13039/100012304, School of Medicine, Johns Hopkins University;

Award ID: none

Award Recipient : Jennifer M. Coughlin Mark J. Soloski

Funded by: FundRef http://dx.doi.org/10.13039/100000002, National Institutes of Health;

Award ID: EB024495

Award Recipient : Martin G. Pomper

Custom metadata

ScienceOpen disciplines: Neurosciences

Keywords: [11c]dpa-713,microglia,post-treatment lyme disease syndrome,neuroimaging

Data availability:

ScienceOpen disciplines: Neurosciences

Keywords: [11c]dpa-713, microglia, post-treatment lyme disease syndrome, neuroimaging