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      NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders

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          Abstract

          OBJECTIVES: Fetal Alcohol Spectrum Disorders (FASD) due to prenatal ethanol consumption may induce long-lasting changes to the newborns affecting also the endocrine system and the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) signaling. Thus the aim of this study was to investigate in the thyroid, testis and adrenal glands of a FASD mouse model the long-lasting effects of ethanol exposure during pregnancy and lactation on NGF and BDNF and their main receptors, TrkA and TrkB, including their phosphorylated patterns. METHODS: We used aged male CD-1 mice early exposed to ethanol solution or red wine at same ethanol concentration (11% vol). RESULTS We found elevations in NGF and BDNF in the thyroid of aged mice exposed to ethanol solution only but not in the red wine group. In the testis NGF resulted to be increased only in the ethanol solution group. In the adrenal glands data showed an elevation in NGF in both the ethanol solution group and red wine. No changes in TrkA, TrkB, phospho-TrkA and phospho-TrkB were revealed in all tissues examined. CONCLUSIONS Early administration of ethanol may induce long-lasting changes in the mouse thyroid, testis and adrenal glands at NGF and BDNF levels.

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          Most cited references27

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          Purkinje cell dysfunction and alteration of long-term synaptic plasticity in fetal alcohol syndrome

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            Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum

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              Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain

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                Author and article information

                Contributors
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                Journal
                aiss
                Annali dell'Istituto Superiore di Sanità
                Ann. Ist. Super. Sanità
                Istituto Superiore di Sanità (Roma )
                0021-2571
                December 2013
                : 49
                : 4
                : 383-390
                Affiliations
                [1 ] Sapienza Università di Roma Italy
                [2 ] Istituto di Biologia Cellulare e Neurobiologia Italy
                [3 ] Istituto Superiore di Sanità Italy
                [4 ] Medical University Austria
                [5 ] Sapienza Università di Rome Italy
                [6 ] Istituto Superiore di Sanità Italy
                Article
                S0021-25712013000400011
                10.4415/ANN_13_04_11
                24334784
                af8af0e0-a086-4d76-bbee-61703e01bb56

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Public Health

                Self URI (journal page): http://www.scielosp.org/scielo.php?script=sci_serial&pid=0021-2571&lng=en
                Categories
                Health Care Sciences & Services

                Health & Social care
                nerve growth factor,brain derived, neurotrophic factor,fetal alcohol spectrum,disorders,FASD

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