Jingyao Qu: Role: Data curationRole: Formal analysisRole: MethodologyRole: Writing – original
draft
Cheng Ma: Role: Data curationRole: MethodologyRole: Writing – original draft
Xiao-Qian Xu: Role: MethodologyRole: Resources
Min Xiao: Role: Writing – review & editing
Junping Zhang: Role: MethodologyRole: Resources
Dong Li: Role: Resources
Ding Liu: Role: Writing – review & editing
Barbara A. Konkle: Role: Writing – review & editing
Carol H. Miao: Role: Writing – review & editing
Lei Li:
ORCID: http://orcid.org/0000-0002-1146-0761
Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review
& editing
Weidong Xiao: Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review
& editing
Valder R. Arruda: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
22
May
2020
Publication date Collection: 2020
Volume: 15
Issue: 5
Electronic Location Identifier: e0233576
Affiliations
[1
]
National Glycoengineering Research Center, Microbial Technology Institute, Shandong
University, Qingdao, Shandong, China
[2
]
Department of Chemistry, Georgia State University, Atlanta, GA, United States of America
[3
]
Department of Hematology, Shanghai Jiaotong University Affiliated Shanghai General
Hospital, Shanghai, China
[4
]
Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, PA, United
States of America
[5
]
Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School
of Medicine, Shanghai, China
[6
]
Bloodworks Northwest, Seattle, WA, United States of America
[7
]
University of Washington, Seattle, WA, United States of America
[8
]
Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, Seattle,
WA, United States of America
University of Pennsylvania Perelman School of Medicine, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-20-02014
DOI: 10.1371/journal.pone.0233576
PMC ID: 7244179
PubMed ID: 32442215
SO-VID: af917d0b-c9db-44a2-a2df-b0d3519fa685
Copyright © © 2020 Qu et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
This work was supported by National Heart, Lung, and Blood Institute (U54HL142019
to W. Xiao, C.H. Miao, L. Li, and B. Konkle). The funder had no role in study design,
data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Glycobiology
Subject:
Glycosylation
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Post-Translational Modification
Subject:
Glycosylation
Subject:
Research and analysis methods
Subject:
Biological cultures
Subject:
Cell lines
Subject:
CHO cells
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Research and analysis methods
Subject:
Biological cultures
Subject:
Cell lines
Subject:
BHK cells
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Analytical Chemistry
Subject:
Mass Spectrometry
Subject:
Matrix-Assisted Laser Desorption Ionization Mass Spectrometry
Subject:
Research and Analysis Methods
Subject:
Spectrum Analysis Techniques
Subject:
Mass Spectrometry
Subject:
Matrix-Assisted Laser Desorption Ionization Mass Spectrometry
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Glycobiology
Subject:
Glycoproteins
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Proteases
Subject:
Serine Proteases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Proteases
Subject:
Serine Proteases
Subject:
Medicine and health sciences
Subject:
Hematology
Subject:
Blood coagulation
Subject:
Coagulation disorders
Subject:
Hemophilia A
Subject:
Medicine and health sciences
Subject:
Cardiovascular medicine
Subject:
Cardiovascular diseases
Subject:
Coagulation disorders
Subject:
Hemophilia A