Contributors
Stephanie A. Montgomery: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Ellen F. Young: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – review & editing
Phillip G. Durham: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – review & editing
Katelyn E. Zulauf: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Laura Rank: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Brittany K. Miller: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Jennifer D. Hayden: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Feng-Chang Lin: Role: Formal analysisRole: Methodology
John T. Welch: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review &
editing
Anthony J. Hickey: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Miriam Braunstein:
ORCID: http://orcid.org/0000-0003-1180-0030
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Ann Rawkins: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
27
September
2018
Publication date Collection: 2018
Volume: 13
Issue: 9
Electronic Location Identifier: e0204495
Affiliations
[1
]
Department of Pathology and Laboratory Medicine and Lineberger Comprehensive Cancer
Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina,
United States of America
[2
]
Department of Microbiology and Immunology, School of Medicine, University of North
Carolina, Chapel Hill, North Carolina, United States of America
[3
]
RTI International, Research Triangle Park, North Carolina, United States of America
[4
]
Department of Biostatistics and North Carolina Translational and Clinical Sciences
Institute, University of North Carolina, Chapel Hill, North Carolina, United States
of America
[5
]
Department of Chemistry, University at Albany, Albany, New York, United States of
America
Public Health England, UNITED KINGDOM
Author notes
Competing Interests: I have read the journal's policy and the authors of this manuscript have the following
competing interests: MB, AJH, PGD and EY have filed a provisional patent PCT/US2017/061544
"Tuberculosis therapeutic compounds and methods”. This does not alter our adherence
to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-18-01227
DOI: 10.1371/journal.pone.0204495
PMC ID: 6160074
PubMed ID: 30261007
SO-VID: af930da7-dc99-4812-b74c-57a9c29a11a7
Copyright © © 2018 Montgomery et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 12
January
2018
Date
accepted
: 10
September
2018
Page count
Figures: 4,
Tables: 4,
Pages: 19
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100006108, National Center for Advancing Translational Sciences;
Award ID: ULTR001111
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1180-0030
Miriam Braunstein
Funded by: funder-id http://dx.doi.org/10.13039/100000001, National Science Foundation;
Award ID: CHE-1337594
Award Recipient
:
John T. Welch
Funded by: funder-id http://dx.doi.org/10.13039/100006108, National Center for Advancing Translational Sciences;
Award ID: ULTR001111
Award Recipient
:
Anthony J. Hickey
Funded by: funder-id http://dx.doi.org/10.13039/100000054, National Cancer Institute;
Award ID: 5P30CA016086-41
Funded by: funder-id http://dx.doi.org/10.13039/100006108, National Center for Advancing Translational Sciences;
Award ID: UL1TR002489
Award Recipient
:
Feng-Chang Lin
This work was supported by the National Center for Advancing Translational Sciences,
National Institutes of Health, through Grant Award 1UL1TR001111 and NC TraCS 4DR31502
awards to MB and AJH and through National Science Foundation grant award CHE-1337594
to JTW. Histopathology was performed by the Animal Histopathology & Laboratory Medicine
Core at the University of North Carolina, UNC Lineberger Comprehensive Cancer Center,
which is supported in part by an NCI Center Core Support Grant (5P30CA016086-41).
National Center for Advancing Translational Sciences (UL1TR002489) to FCL. The funders
had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
Granulomas
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
Granulomas
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
Granulomas
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Actinobacteria
Subject:
Mycobacterium Tuberculosis
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Spleen
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Spleen
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Bacterial Diseases
Subject:
Tuberculosis
Subject:
Medicine and Health Sciences
Subject:
Tropical Diseases
Subject:
Tuberculosis
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Guinea Pigs
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rodents
Subject:
Guinea Pigs
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials by Structure
Subject:
Powders
Subject:
Medicine and Health Sciences
Subject:
Pharmaceutics
Subject:
Drug Therapy
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Necrosis
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Necrosis
Custom metadata
