1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Mitochondrial Sirtuins and Molecular Mechanisms of Aging

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Advancing age is the major risk factor for the development of chronic diseases and is accompanied with changes in metabolic processes and mitochondrial dysfunction. Mitochondrial sirtuins (SIRT3-5) are part of the sirtuin family of NAD +-dependent deacylases and ADP-ribosyl transferases. The dependence on NAD + links sirtuin enzymatic activity to the metabolic state of the cell, poising them as stress sensors. Recent insights have revealed that SIRT3-5 orchestrate stress responses through coordinated regulation of substrate clusters rather than a few key metabolic enzymes. Additionally, mitochondrial sirtuin function has been implicated in the protection against age-related pathologies including neurodegeneration, cardiopathologies and insulin resistance. In this review, we highlight the molecular targets of SIRT3-5 and discuss their involvement in aging and age-related pathologies.

          Related collections

          Author and article information

          Journal
          100966035
          22040
          Trends Mol Med
          Trends Mol Med
          Trends in molecular medicine
          1471-4914
          1471-499X
          17 March 2017
          10 March 2017
          April 2017
          01 April 2018
          : 23
          : 4
          : 320-331
          Affiliations
          [1 ]Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
          Author notes
          [# ]correspondence: marcia_haigis@ 123456hms.harvard.edu (M.C. Haigis)
          [*]

          equal contribution

          Article
          PMC5713479 PMC5713479 5713479 nihpa855399
          10.1016/j.molmed.2017.02.005
          5713479
          28285806
          Categories
          Article

          Comments

          Comment on this article