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      Polymer-modified fibrous mesoporous silica nanoparticles as coating material for open-tubular capillary electrochromatography.

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          Abstract

          A novel fibrous mesoporous silica nanoparticles (fSiO2) stationary phase grafted with polymer (Poly (2-(dimethylamino) ethyl methacrylate) (PDMAEMA) was developed for open tubular capillary electrochromatography (OT-CEC). The preparation procedure included synthesizing fSiO2 through biphase stratification approach, removing the surfactants, silanization and in situ graft polymerization with monomers via atom transfer radical polymerization (ATRP). Subsequently, PDMAEMA-modified mesoporous silica nanoparticles (P-fSiO2)/ethanol solution was immobilized onto the inner surface of the pretreated capillary and functionalized with octadecylsilane to fabricate the open-tubular column. Separation of polycyclic aromatic hydrocarbons (PAHs) and proteins were carried out to evaluate the performance of the column in CEC. The run-to-run, day-to-day and column-to-column reproducibility in terms retention time of naphthalene was 1.9%, 2.2%, and 3.7%, respectively. The effects of solvent concentration and pH on the separation were evaluated. The method was also used for the separation of real bio-sample, egg white proteins.

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          Author and article information

          Journal
          J Chromatogr A
          Journal of chromatography. A
          Elsevier BV
          1873-3778
          0021-9673
          May 26 2017
          : 1499
          Affiliations
          [1 ] School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
          [2 ] Key Laboratory of Functional Molecule Design and Interface Process, School of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei 230601, China.
          [3 ] School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: chaoyan@sjtu.edu.cn.
          Article
          S0021-9673(17)30485-5
          10.1016/j.chroma.2017.03.074
          28396086

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