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      Vascular Alterations in Adenomas of Human Pituitary Glands

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      Journal of Vascular Research

      S. Karger AG

      Pituitary gland, Pituitary adenoma, Ultrastructure, Vessels, Vascular lesions

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          Abstract

          Electron microscopy of 18 human pituitary adenomas revealed vascular abnormalities consisting of thickening of endothelial lining, endothelial swelling, endothelial blebbing, accumulation of microfilaments in the cytoplasm of the endothelial cells, partial or total loss of fenestration, and, rarely, thickening of basement membrane. Disturbance of pituitary microcirculation, possibly due to alteration of intrahypophysial pressure, can result in hypoxia. This might play an important role in the genesis of changes of vasculature. Lesions of the pituitary vessels occur not infrequently. If severe, they may interfere with exchanges of O<sub>2</sub> and metabolic products and may alter permeability across the vascular walls. Their further progress may cause irreversible damage to the tumor cells, leading ultimately to hemorrhage and infarction of the tumor.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1973
          1973
          18 September 2008
          : 10
          : 5-6
          : 299-309
          Affiliations
          Department of Pathology, St. Michael’s Hospital, University of Toronto, Toronto, Ont.
          Article
          157987 Angiologica 1973;10:299–309
          10.1159/000157987
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Paper

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