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      Vascular Alterations in Adenomas of Human Pituitary Glands


      Journal of Vascular Research

      S. Karger AG

      Pituitary gland, Pituitary adenoma, Ultrastructure, Vessels, Vascular lesions

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          Electron microscopy of 18 human pituitary adenomas revealed vascular abnormalities consisting of thickening of endothelial lining, endothelial swelling, endothelial blebbing, accumulation of microfilaments in the cytoplasm of the endothelial cells, partial or total loss of fenestration, and, rarely, thickening of basement membrane. Disturbance of pituitary microcirculation, possibly due to alteration of intrahypophysial pressure, can result in hypoxia. This might play an important role in the genesis of changes of vasculature. Lesions of the pituitary vessels occur not infrequently. If severe, they may interfere with exchanges of O<sub>2</sub> and metabolic products and may alter permeability across the vascular walls. Their further progress may cause irreversible damage to the tumor cells, leading ultimately to hemorrhage and infarction of the tumor.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 10
          : 5-6
          : 299-309
          Department of Pathology, St. Michael’s Hospital, University of Toronto, Toronto, Ont.
          157987 Angiologica 1973;10:299–309
          © 1973 S. Karger AG, Basel

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          Page count
          Pages: 11


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