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      Wireless and Simultaneous Detections of Multiple Bio-Molecules in a Single Sensor Using Love Wave Biosensor

      research-article
      1 , 2 , 1 , 2 , *
      Sensors (Basel, Switzerland)
      MDPI
      SAW, love wave, biosensor, wireless, batteryfree, IgG, COMP, antenna

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          Abstract

          A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein (COMP) and rabbit immunoglobulin G (IgG) in a single sensor. The developed biosensor consists of one-port surface acoustic wave (SAW) reflective delay lines on a 41° YX LiNbO 3 piezoelectric substrate, a poly(methyl methacrylate) (PMMA) waveguide layer, and two different sensitive films. The Love wave biosensor was wirelessly characterized using two antennas and a network analyzer. The binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks mainly due to the mass loading effect. The assessed time shifts in the reflection peaks were matched well with the predicted values from coupling of mode (COM) modeling. The sensitivities evaluated from the sensitive films were ∼15 deg/μg/mL for the rabbit IgG and ∼1.8 deg/ng/mL for COMP.

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          Most cited references45

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          Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis

          Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheumatoid arthritis and osteoarthritis, it becomes important to identify prognostic factors that can predict the evolution of arthritis. This is especially critical in the early phases of disease so that these treatments can be started as soon as possible to slow down progression of the disease. A valuable approach to monitor arthritis would be by measuring biological markers of cartilage degradation and repair to reflect variations in joint remodeling. One such potential biological marker of arthritis is cartilage oligomeric matrix protein (COMP). In various studies, COMP has shown promise as a diagnostic and prognostic indicator and as a marker of the disease severity and the effect of treatment. This review highlights the progress in the utilization of COMP as a biomarker of arthritis.
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            A novel Love-plate acoustic sensor utilizing polymer overlayers.

            A Love-plate sensor, consisting of a surface skimming bulk wave (SSBW) device coated with a polymer layer, was found to increase the acoustic signal through coupling of the SSBW wave to a Love wave. Insertion loss, phase and frequency measurements were used to assess the optimum thickness of the polymer layer and the sensitivity of the device to mass-loading and viscous coupling.
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              Properties of Love waves: applications in sensors

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                Author and article information

                Journal
                Sensors (Basel)
                Sensors (Basel)
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                November 2014
                17 November 2014
                : 14
                : 11
                : 21660-21675
                Affiliations
                [1 ] Korea Electronics Technology Institute, Seongnam-si, Gyeonggi-do 463-816, Korea; E-Mails: ajounasa@ 123456gmail.com (H.O.); kimkn@ 123456keti.re.kr (K.K.)
                [2 ] Department of Electronics Engineering, Ajou University, Suwon, Gyeonggi-do 443-749, Korea; E-Mail: fuchen92@ 123456hotmail.com
                Author notes

                External Editor: Benoit Gosselin

                [* ] Author to whom correspondence should be addressed; E-Mail: keekeun@ 123456ajou.ac.kr ; Tel.: +82-31-219-1848; Fax: +82-31-212-9531
                Article
                sensors-14-21660
                10.3390/s141121660
                4279554
                25407905
                afccd82e-133d-4ca7-8238-a772903a81f1
                © 2014 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 27 August 2014
                : 15 October 2014
                : 24 October 2014
                Categories
                Article

                Biomedical engineering
                saw,love wave,biosensor,wireless,batteryfree,igg,comp,antenna
                Biomedical engineering
                saw, love wave, biosensor, wireless, batteryfree, igg, comp, antenna

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