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      Surgically treated osteonecrosis and osteomyelitis of the jaw and oral cavity in patients highly adherent to alendronate treatment: a nationwide user-only cohort study including over 60,000 alendronate users.

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          Abstract

          Osteonecrosis of the jaw (ONJ) is rare (2.53/10,000 person-years) among alendronate users, but long-term and compliant use are associated with an increased risk of surgically treated ONJ. Risk of surgically treated ONJ is higher in patients with rheumatoid diseases and use of proton pump inhibitors.

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          Author and article information

          Journal
          Osteoporos Int
          Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
          Springer Nature America, Inc
          1433-2965
          0937-941X
          October 2017
          : 28
          : 10
          Affiliations
          [1 ] Department of Cardiology, Nephrology and Endocrinology, North Zealand Hospital, Hillerød, Dyrehavevej 29, 3400, Hillerød, Denmark. piei@regionh.dk.
          [2 ] Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. piei@regionh.dk.
          [3 ] Musculoskeletal Pharmaco and Device Epidemiology, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK.
          [4 ] GREMPAL Research Group and CIBERFes, Idiap Jordi Gol, Universitat Autònoma de Barcelona and Instituto Carlos III (FEDER Research Funds), Av Gran Via Corts Catalanes 185, 08003, Barcelona, Spain.
          [5 ] Academic Unit of Bone Metabolism (AUBM), University of Sheffield, Herries Road, Sheffield, S5 7AU, UK.
          [6 ] Department of Clinical Research, Odense Patient Data Explorative Network, University of Southern Denmark, J.B. Winsløws Vej 9 A, 3. Sal, 5000, Odense, Denmark.
          [7 ] Department of Medicine, Holbæk Hospital, Smedelundsgade 60, 4300, Holbæk, Denmark.
          Article
          10.1007/s00198-017-4132-y
          10.1007/s00198-017-4132-y
          28664276
          afe95bf3-e7d6-4a10-9fad-92e2f4c41bfc
          History

          Alendronate,Biphosphonates,Epidemiology,Osteomyelitis of the jaw,Osteonecrosis of the jaw,Risk factors,Surgery

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