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      Bipolarins A–H, eight new ophiobolin-type sesterterpenes with antimicrobial activity from fungus Bipolaris sp. TJ403-B1

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          Abstract

          Bipolarins A–H ( 18), eight new tetracyclic ophiobolin-type sesterterpenes featuring a rare oxaspiro[4.4]nonane moiety, were isolated from cultures of fungus Bipolaris sp. TJ403-B1. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, electronic circular dichroism and 13C NMR calculations. Additionally, compound 5 exhibited significant selective antimicrobial activity against Enterococcus faecalis with an MIC value 8 μg·mL −1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 935-944
          Affiliations
          1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
          2 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
          Author notes
          *Corresponding author: ZHANG Yong-Hui, Tel: 86-27-83692892, E-mails: zhangyh@ 123456mails.tjmu.edu.cn , HU Zheng-Xi, hzx616@ 123456126.com

          Δ These authors contributed equally to this work.

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30116-5
          10.1016/S1875-5364(19)30116-5
          31882049
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China
          Award ID: T2016088
          Funded by: National Natural Science Foundation for Distinguished Young Scholars
          Award ID: 81725021
          Funded by: Innovative Research Groups of the National Natural Science Foundation of China
          Award ID: 81721005
          Funded by: National Natural Science Foundation of China
          Award ID: 81573316
          Funded by: National Natural Science Foundation of China
          Award ID: 21702067
          Funded by: National Natural Science Foundation of China
          Award ID: 81803387
          Funded by: Hubei Provincial Natural Science Foundation of China
          Award ID: 2018CFB152
          This work was supported by the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China (No. T2016088), the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021), the Innovative Research Groups of the National Natural Science Foundation of China (No. 81721005), the National Natural Science Foundation of China (Nos. 81573316, 21702067, and 81803387), and the Hubei Provincial Natural Science Foundation of China (No. 2018CFB152).
          Categories
          Research article

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