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      Collagen-Induced Arthritis Models.

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          Abstract

          Due to limitations of using patient-derived samples for systemic kinetic studies in rheumatoid arthritis (RA) research, animal models are helpful for further understanding the pathophysiology of RA and seeking potential therapeutic targets or strategies. The collagen-induced arthritis (CIA) model is one of the standard RA models used in preclinical research. The CIA model shares several pathological features with RA, such as breach of tolerance and generation of autoantibodies targeting collagen, synovial inflammatory cell infiltration, synovial hyperplasia, cartilage destruction, and bone erosion. In this chapter, a protocol for successful induction of CIA in mice is described. In this protocol, CIA is induced by active immunization by inoculation with type II heterologous collagen in Freund's adjuvant in susceptible DBA/1 mice.

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          Author and article information

          Journal
          Methods Mol. Biol.
          Methods in molecular biology (Clifton, N.J.)
          Springer Nature
          1940-6029
          1064-3745
          2018
          : 1868
          Affiliations
          [1 ] Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
          [2 ] Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. liussmzk@m.ehime-u.ac.jp.
          Article
          10.1007/978-1-4939-8802-0_1
          30244448
          aff9b4c6-f20d-4e59-a7ca-cbedb49ecaaa
          History

          Emulsion,Collagen-induced arthritis,Freund’s adjuvant,Immunization,Type II collagen

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