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      Prospective association of liver function biomarkers with development of hepatobiliary cancers.

      1 , 2 , 1 , 1 , 1 , 3 , 4 , 5 ,   6 , 7 , 7 ,   8 , 9 , 9 , 9 , 10 , 10 , 11 , 11 , 12 , 5 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ,   26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 34 , 34 , 1 , 35

      Cancer epidemiology

      Elsevier BV

      Biological markers, Hepatobiliary cancer, Liver function test, Nested case-control study, Prospective cohort

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          Abstract

          Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers.

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          Author and article information

          Journal
          Cancer Epidemiol
          Cancer epidemiology
          Elsevier BV
          1877-783X
          1877-7821
          Feb 2016
          : 40
          Affiliations
          [1 ] Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
          [2 ] Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, USA.
          [3 ] Laboratoire Lyon République, Lyon, France.
          [4 ] Hellenic Health Foundation, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece.
          [5 ] Hellenic Health Foundation, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
          [6 ] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway; Department of Research, Cancer Registry of Norway, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Samfundet Folkhälsan, Helsinki, Finland.
          [7 ] Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
          [8 ] Department of Public Health, Section for Epidemiology, Aarhus, Aarhus University, Denmark.
          [9 ] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France; Institut Gustave Roussy, Villejuif, France.
          [10 ] Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
          [11 ] Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.
          [12 ] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; Department of Epidemiology, Harvard School of Public Health, Boston, USA.
          [13 ] Hellenic Health Foundation, Athens, Greece; Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Hellenic Health Foundation, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
          [14 ] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
          [15 ] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
          [16 ] Cancer Registry and Histopathology Unit, "Civic-M.P. Arezzo" Hospital, ASP Ragusa, Italy.
          [17 ] Molecular and Genetic Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino, Italy.
          [18 ] Dipartamento di Medicina Clinicae Chirurgias, Federico II University, Naples, Italy.
          [19 ] Dt. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands,; Dt. of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
          [20 ] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
          [21 ] epartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromso, Norway.
          [22 ] Public Health Directorate, Asturias, Spain.
          [23 ] Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain.
          [24 ] Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs, GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; CIBER Epidemiology and Public Health-CIBERESP, Spain.
          [25 ] Public Health Direction and Biodonostia-Ciberesp, Basque Regional Health Department, San Sebastian, Spain.
          [26 ] CIBER Epidemiology and Public Health-CIBERESP, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
          [27 ] CIBER Epidemiology and Public Health-CIBERESP, Spain; Navarre Public Health Institute, Pamplona, Spain.
          [28 ] Department of Clinical Sciences, Division of Internal Medicine, SUS Malmö, Lund University, Malmo, Sweden.
          [29 ] Department of Clinical Sciences, Division of Internal Medicine, SUS Malmö, Lund University, Malmo, Sweden; Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.
          [30 ] Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden.
          [31 ] Department of Surgery, Department of Perioperative and Surgical Sciences, Umea University, Umea, Sweden.
          [32 ] University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge, United Kingdom.
          [33 ] Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom.
          [34 ] Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.
          [35 ] Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France. Electronic address: jenabm@iarc.fr.
          Article
          S1877-7821(16)00004-7
          10.1016/j.canep.2016.01.002
          26773278

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