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      Plasma Levels of Dehydroepiandrosterone and 17β-Estradiol after Intramuscular Administration of Gynodian-Depot® in 3 Women


      Hormone Research in Paediatrics

      S. Karger AG

      Gynodian-Depot®, Pharmacokinetics, Drug levels in plasma, Female menopause

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          Gynodian-Depot® is well suited for treatment of the characteristic symptoms accompanying the menopause in women. The plasma levels of prasterone and 17β-estradiol after intramuscular injection of Gynodian-Depot in women were studied using a radioimmunological method. The maximum active ingredient concentrations were found in the plasma of the subjects only a few days after administration. The depot action lasted on an average 14 days (17β-estradiol) and 18 days (prasterone) after administration, respectively. Prasterone enanthate is completely hydrolysed into the free steroid and the fatty acid.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 17
          : 2
          : 84-89
          Research Laboratories, Schering, Berlin/Bergkamen
          179680 Horm Res 1983;17:84–89
          © 1983 S. Karger AG, Basel

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          Pages: 6


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