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      Age-related hearing loss: biological aspects

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      Author(s): 1 , , 1
      Publication date (Electronic):
      Journal: BMC Geriatrics
      Publisher: BioMed Central
      Conference name: de Senectute: Age and Health Forum
      Conference date: 5–7 December 2009

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          Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures.

          Douglas P Kiel, A Cupples, David Karasik … (2005)
          The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%. The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans.
          Article 0 comments Cited 46 times – based on 0 reviews     Review now
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            Stress resistance and aging: influence of genes and nutrition.

            Justin Miller, Michael Bonkowski, Andrzej Bartke … (2006)
            Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf (dw/dw), Ames dwarf (df/df) and growth hormone receptor knockout (GHR-KO) mouse stocks are resistant, in vitro, to the cytotoxic effects of hydrogen peroxide, cadmium, ultraviolet light, paraquat, and heat. Here we show that, in contrast, fibroblasts from mice on low-calorie (CR) or low methionine (Meth-R) diets are not stress resistant in culture, despite the longevity induced by both dietary regimes. A second approach, involving induction of liver cell death in live animals using acetaminophen (APAP), documented hepatotoxin resistance in the CR and Meth-R mice, but dw/dw and GHR-KO mutant mice were not resistant to this agent, and were in fact more susceptible than littermate controls to the toxic effects of APAP. These data thus suggest that while resistance to stress is a common characteristic of experimental life span extension in mice, the cell types showing resistance may differ among the various models of delayed or decelerated aging.
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              Presbycusis study of a relatively noise-free population in the Sudan.

              Lindsey B. Rosen, Casey M. Bergman, M Satti … (1962)
              Article 0 comments Cited 13 times – based on 0 reviews     Review now
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                Author and article information

                Conference
                Journal ID (nlm-ta): BMC Geriatr
                Title: BMC Geriatrics
                Publisher: BioMed Central
                ISSN (Electronic): 1471-2318
                Publication date Collection: 2010
                Publication date (Electronic): 19 May 2010
                Volume: 10
                Issue: Suppl 1
                Page: L57
                Affiliations
                [1 ]“Magna Graecia” University, Catanzaro, Italy, Experimental and Clinical Medicine Department, Audiology and Phoniatrics Chair, Regional Center for Cochlear Implants and ENT Diseases
                Article
                Publisher ID: 1471-2318-10-S1-L57
                DOI: 10.1186/1471-2318-10-S1-L57
                PMC ID: 3290299
                SO-VID: b02e53ba-6a32-485f-804f-10f256f99985
                Copyright © Copyright ©2010 Cassandro and Chiarella; licensee BioMed Central Ltd.
                Conference name: de Senectute: Age and Health Forum
                Conference location: Catanzaro, Italy
                Conference date: 5–7 December 2009
                History
                Categories
                Subject: Lecture presentation

                ScienceOpen disciplines: Geriatric medicine
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                ScienceOpen disciplines: Geriatric medicine

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