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      Collateral sensitivity of antibiotic-resistant microbes

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          Abstract

          Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it could be exploited for the development of alternative antimicrobial strategies.

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          Author and article information

          Journal
          9310916
          8474
          Trends Microbiol
          Trends Microbiol.
          Trends in microbiology
          0966-842X
          1878-4380
          15 May 2018
          25 March 2015
          July 2015
          18 May 2018
          : 23
          : 7
          : 401-407
          Affiliations
          Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
          Author notes
          Corresponding author: Pál, C. ( cpal@ 123456brc.hu ).
          Article
          PMC5958998 PMC5958998 5958998 ems77767
          10.1016/j.tim.2015.02.009
          5958998
          25818802
          b032ef5e-3c1e-41a5-83d0-f618609c91eb
          History
          Categories
          Article

          multidrug resistance,cross-resistance,experimental evolution,antibiotic resistance,collateral sensitivity

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