16
views
0
recommends
+1 Recommend
0 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes

      research-article
      1 , 2 , 3 , 2 , *
      PLoS ONE
      Public Library of Science

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes.

          Methods

          Longitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. All eyes had glaucomatous optic neuropathy or ocular hypertension, but normal SAP and FDT results at baseline. The development of glaucomatous VF defects was defined as the presence of a cluster of ≥ 3 (less conservative) or ≥ 4 (more conservative) locations confirmed on ≥ 2 additional consecutive tests. Risk factors for the development of VF defects were analyzed by COX proportional hazard models. After conversion into common logarithmic units, the rates of change of global VF indices were fitted with linear mixed models.

          Results

          FDT detected more eyes that developed VF defects than SAP using the less conservative criterion, and no significant difference was observed using the more conservative criterion. For those eyes detected by both SAP and FDT, FDT detected the development of VF defects either earlier than SAP or simultaneously in most cases. Baseline structural measurements were not significantly associated with an increased risk for the development of glaucomatous VF defects on either SAP or FDT. Older age was significantly associated with the development of VF defects on FDT but not on SAP. Both SAP and FDT detected a progressing worsening trend of pattern standard deviation over time with a similar rate of change between these test types.

          Conclusions

          Matrix FDT would be useful to monitor the onset of VF defects in glaucoma suspects and may outperform SAP in the early stage of glaucomatous VF damage.

          Related collections

          Most cited references41

          • Record: found
          • Abstract: found
          • Article: not found

          The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.

          The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            'Structure-function relationship' in glaucoma: past thinking and current concepts.

            An understanding of the relationship between functional and structural measures in primary open-angle glaucoma is necessary for both grading the severity of disease and for understanding the natural history of the condition. This article outlines the current evidence for the nature of this relationship and highlights the current mathematical models linking structure and function. Large clinical trials demonstrate that both structural and functional change are apparent in advanced stages of disease, and at an individual level, detectable structural abnormality may precede functional abnormality in some patients, whereas the converse is true in other patients. Although the exact nature of the 'structure-function' relationship in primary open-angle glaucoma is still the topic of scientific debate and the subject of continuing research, this article aims to provide the clinician with an understanding of the past concepts and contemporary thinking in relation to the structure-function relationship in primary open-angle glaucoma.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data.

              To identify factors accounting for differences in glaucoma onset and rate of progression between individuals of African descent and European descent. A prospective, multicenter observational cohort study of 1221 participants of African descent and European descent with no glaucoma (normal), suspected glaucoma, and glaucoma. Six hundred eighty-six patient participants in the African Descent and Glaucoma Evaluation Study will be followed up longitudinally. Four hundred thirty-six participants of European descent from the Diagnostic Innovations in Glaucoma Study (DIGS) were also included. Baseline demographics, visual function (standard automated perimetry, short-wavelength automated perimetry, frequency doubling technology perimetry), optic nerve structure (retina tomography, optical coherence tomography), clinical status, and risk factors were measured. Individuals of African descent had (1) thinner corneas (P < .001) across all diagnostic groups, (2) a higher percentage of reported diabetes mellitus (P < .001) and high blood pressure (P < .001) and a lower percentage of reported heart disease (P = .001), and (3) worse pattern standard deviation for standard automated perimetry fields overall (P = .001) and within normal limits (P = .01) than individuals of European descent. No differences were present for mean intraocular pressure (P = .79). Significant baseline differences were found in a number of clinical findings between persons of African descent compared with European descent. Longitudinal data from the African Descent and Glaucoma Evaluation Study will be important for determining which baseline features are important and predictive for accurate diagnosis and follow-up in this high-risk group. Trial Registration clinicaltrials.gov Identifier: NCT00221923.
                Bookmark

                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                18 May 2017
                2017
                : 12
                : 5
                : e0178079
                Affiliations
                [1 ]Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
                [2 ]Indiana University, Eugene and Marilyn Glick Eye Institute, Indianapolis, Indiana, United States of America
                [3 ]Indiana University, Fairbanks School of Public Health, Indianapolis, Indiana, United States of America
                Bascom Palmer Eye Institute, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                • Conceptualization: RH LR.

                • Data curation: RH CW LR.

                • Formal analysis: RH CW LR.

                • Funding acquisition: RH LR.

                • Investigation: RH CW LR.

                • Methodology: RH CW LR.

                • Project administration: LR.

                • Resources: RH CW LR.

                • Software: RH CW LR.

                • Supervision: LR.

                • Validation: RH CW LR.

                • Visualization: RH CW LR.

                • Writing – original draft: RH LR.

                • Writing – review & editing: RH CW LR.

                [¤]

                Current address: Vertex Pharmaceuticals Inc., Boston, Massachusetts, United States of America

                Author information
                http://orcid.org/0000-0002-2238-3431
                Article
                PONE-D-17-02158
                10.1371/journal.pone.0178079
                5436878
                28542536
                b03747ab-c6bc-418c-af8d-c6ddbb0dd79e
                © 2017 Hu et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 21 January 2017
                : 6 May 2017
                Page count
                Figures: 3, Tables: 3, Pages: 14
                Funding
                This research was supported by NIH grant EY025756 (LR) and by grants from the Zhejiang Provincial Natural Science Foundation of China (grant no: LQ17H120003 and LY13H120003, RH) and from the Health and Family Planning Commission of Zhejiang Province, China (grant no: 2016KYA089, RH). Acknowledgment is made to the donors of the National Glaucoma Research, a program of BrightFocus Foundation (LR), for support of this research. This work was also supported in part by a Shaffer grant from the Glaucoma Research Foundation (LR), by an Indiana University—Purdue University Indianapolis DRIVE award (LR), and by an unrestricted grant from Research to Prevent Blindness (LR). The DIGS and ADAGES studies were supported by NIH Grants P30EY022589, EY021818, EY11008, U10EY14267, EY019869; Eyesight Foundation of Alabama; Edith C. Blum Research Fund of the New York Glaucoma Research Institute, New York, NY; and unrestricted grant from Research to Prevent Blindness, New York, New York. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Biology and Life Sciences
                Anatomy
                Head
                Eyes
                Medicine and Health Sciences
                Anatomy
                Head
                Eyes
                Biology and Life Sciences
                Anatomy
                Ocular System
                Eyes
                Medicine and Health Sciences
                Anatomy
                Ocular System
                Eyes
                Medicine and Health Sciences
                Ophthalmology
                Eye Diseases
                Glaucoma
                Medicine and Health Sciences
                Ophthalmology
                Medicine and Health Sciences
                Vascular Medicine
                Blood Pressure
                Hypertension
                Medicine and Health Sciences
                Neurology
                Neuropathy
                Optic Neuropathy
                Medicine and Health Sciences
                Ophthalmology
                Eye Diseases
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Regression Analysis
                Linear Regression Analysis
                Physical Sciences
                Mathematics
                Statistics (Mathematics)
                Statistical Methods
                Regression Analysis
                Linear Regression Analysis
                Biology and Life Sciences
                Neuroscience
                Sensory Perception
                Vision
                Biology and Life Sciences
                Psychology
                Sensory Perception
                Vision
                Social Sciences
                Psychology
                Sensory Perception
                Vision
                Custom metadata
                All relevant data are within the paper and its Supporting Information files.

                Uncategorized
                Uncategorized

                Comments

                Comment on this article