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      Ethnic difference in contribution of Sp1 site variation of COLIA1 gene in genetic predisposition to osteoporosis.

      Calcified Tissue International
      Aged, Alleles, Asian Continental Ancestry Group, Base Sequence, Bone Density, physiology, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, ethnology, genetics, Genetic Variation, Genotype, Heterozygote, Humans, Molecular Sequence Data, Oncogene Proteins, Fusion, Osteoporosis, Postmenopausal, Polymorphism, Restriction Fragment Length

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          Abstract

          Osteoporosis, a condition characterized by low bone mineral density (BMD) leading to bone fragility [1], is a major public health concern in Japan as well as in other countries. Although genetic predisposition seems to be a factor in the pathogenesis of osteoporosis [2-4], the precise cohort of genes that may be involved is not well defined. The COLIA1 and COLIA2 genes encode polypeptide constituents of collagen type Ialpha1 and Ialpha2, respectively. Both are important candidates as genetic regulators of BMD, since mutations in either gene result in osteogenesis imperfecta, a disorder characterized by severe osteoporosis [5]. Some patients with adult osteoporosis also carry mutations in COLIA1 or COLIA2 genes [6].http://link.springer-ny. com/link/service/journals/00223/bibs/65n5p352.html

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