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      Anti-Taenia solium metacestode IgG antibodies in serum samples from inhabitants of a central-western region of Brazil Translated title: Anticorpos IgG anti-metacestódeo de Taenia solium em amostras de soro de habitantes da região centro-oeste do Brasil

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          Abstract

          A total of 354 serum samples from inhabitants who frequent the Clinical Laboratory in Catalão, Goiás, in the central-western region of Brazil, were collected from June to August, 2002. The samples were evaluated by indirect immunofluorescence antibody tests and an enzyme linked immunosorbent assay in order to detect anti-Taenia solium metacestode IgG antibodies. Reactive and inconclusive samples were tested by Western blotting (WB). Considering WB as a confirmation, the frequency of antibodies in the serum samples of the above population was 11.3% (CI 5.09 - 17.51). The immunodominant bands most frequently recognized in WB were 64-68 kDa (97.5%) and 47-52 kDa (80%). The percentage of seropositivity to cysticercosis was significantly higher for individuals residing in areas without sewage systems (p < 0.0001). In conclusion, the results indicate a probable endemic situation of cysticercosis in this population. These results reinforce the urgent need for control and prevention measures to be taken by the local public health services.

          Translated abstract

          Um total de 354 amostras de soro de habitantes que freqüentaram o Laboratório Clínico em Catalão, Goiás, na região centro-oeste do Brasil, foram colhidas no período de junho a agosto de 2002. As amostras foram avaliadas pelo teste de imunofluorescência indireta e enzyme-linked immunosorbent assay (ELISA) com o objetivo de detectar anticorpos IgG anti-metacestódeo de Taenia solium. As amostras reativas e inconclusivas foram testadas pelo Western blotting (WB). Considerando WB como reação confirmatória, a freqüência de anticorpos nas amostras de soro da população estudada foi 11,3% (IC: 5,09 - 17,51). As bandas imunodominantes mais frequentemente reconhecidas no WB foram 64-68 kDa (97,5%) e 47-52 kDa (80%). A porcentagem de soropositividade para cisticercose foi significativamente maior nos indivíduos que residiam em áreas sem sistema de esgoto (p < 0,0001). Concluiu-se que os resultados indicam uma provável situação de endemicidade para cisticercose nesta população, reforçando a urgente necessidade de medidas de controle e prevenção que devem ser implantadas pelo serviço de saúde pública local.

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          Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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            Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

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              Neurocysticercosis: regional status, epidemiology, impact and control measures in the Americas.

              The analysis of epidemiological data concerning human cysticercosis point to important advances in understanding the magnitude and distribution of this parasitic disease in Latin America, as well as the relationship of the elements that conform the life cycle of Taenia solium. The data indicate that the main risk factor for acquiring human neurocysticercosis and swine cysticercosis is the presence of the tapeworm carrier in the household. Therefore, several intervention measures for the control of cysticercosis have been evaluated: mass treatment in order to cure tapeworm carriers, health education towards understanding the risk factors, pig control by restraining them, experimental vaccination of pigs and treatment of swine cysticercosis. In this paper, we review the information obtained in these areas. We hope it will be useful in other endemic countries that wish to elaborate an action plan for the control and ultimate eradication of T. solium.
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                Author and article information

                Journal
                rimtsp
                Revista do Instituto de Medicina Tropical de São Paulo
                Rev. Inst. Med. trop. S. Paulo
                Instituto de Medicina Tropical (São Paulo, SP, Brazil )
                1678-9946
                February 2006
                : 48
                : 1
                : 49-52
                Affiliations
                [01] MG orgnameUniversidade Federal de Uberlândia orgdiv1Instituto de Ciências Biomédicas orgdiv2Laboratório de Parasitologia Brasil
                Article
                S0036-46652006000100011 S0036-4665(06)04800111
                10.1590/S0036-46652006000100011
                16547581
                b06fbf1d-5520-408a-a918-1877b560dfbd

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 27 October 2005
                : 11 July 2005
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 19, Pages: 4
                Product

                SciELO Brazil

                Categories
                Brief communication

                Cysticercosis,Taenia solium,Brazil,Immunodiagnosis
                Cysticercosis, Taenia solium, Brazil, Immunodiagnosis

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