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Development and Progression of Uremic Changes in the Mouse with Surgically Induced Renal Failure
Abstract
Adult C57BL/6 mice with surgically induced renal failure of 1–15 weeks’ duration were examined forthe presence of changes caused by the renal failure. Surgery consisted of the electrocoagulation of the entire surface of the right kidney followed 3 weeks later by contralateral nephrectomy. Control groups comprised normal mice as well as sham-operated mice subjected to the right kidney electrocoagulation followed by visualization of the left kidney rather than removal. Results indicate: (1) the surgical procedures to induce renal failure were free of local and systemic infectious complications, (2) moderate to severe degree of renal failure was consistently achieved and remained stable over the study period, (3) significant growth retardation of the renal failure mice was present throughout the study whereas sham-operated mice showed catch-up growth with normal controls by the 3rd week postsurgery, (4) anemia was a very early manifestation of the disease appearing by the 1st week after the induction of renal failure to reach its nadir by the 2nd week; a mild anemia was observed transiently postsurgery in sham-operated mice and ascribed to the renal injury, and (5) renal failure mice were free of visible changes of advanced uremia such as impaired wound healing, bleeding tendency and gross neurological deficits. This new experimental model is proposed as a tool for the study of the pathogenesis and treatment of chronic uremia. While developed to study the immunological disturbances of renal failure, this model could conceivably serve for the study of other abnormalities, anemia in particular.
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185812 Nephron 1990;54:70–76Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.