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      Exercise training can induce cardiac autophagy at end-stage chronic conditions: insights from a graft-versus-host-disease mouse model.

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          Abstract

          Chronic graft-versus-host disease (cGVHD) is a frequent cause of morbimortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and severely compromises patients' physical capacity. Despite the aggressive nature of the disease, aerobic exercise training can positively impact survival as well as clinical and functional parameters. We analyzed potential mechanisms underlying the recently reported cardiac function improvement in an exercise-trained cGVHD murine model receiving lethal total body irradiation and immunosuppressant treatment (Fiuza-Luces et al., 2013. Med Sci Sports Exerc 45, 1703-1711). We hypothesized that a cellular quality-control mechanism that is receiving growing attention in biomedicine, autophagy, was involved in such improvement.

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          Author and article information

          Journal
          Brain Behav. Immun.
          Brain, behavior, and immunity
          Elsevier BV
          1090-2139
          0889-1591
          Jul 2014
          : 39
          Affiliations
          [1 ] European University and Hospital Universitario 12 de Octubre Research Institute (i+12), Madrid, Spain.
          [2 ] Mitochondrial and Neuromuscular Diseases Laboratory, Hospital Universitario 12 de Octubre Research Institute (i+12), Madrid, Spain; Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain.
          [3 ] Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal.
          [4 ] Children's University Hospital Niño Jesús, Madrid, Spain.
          [5 ] Centre of Energy, Environment and Technical Research (CIEMAT), Madrid, Spain.
          [6 ] Mitochondrial and Neuromuscular Diseases Laboratory, Hospital Universitario 12 de Octubre Research Institute (i+12), Madrid, Spain; Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain. Electronic address: mmoran@12o.es.
          Article
          S0889-1591(13)00538-2
          10.1016/j.bbi.2013.11.007
          24239952
          b08834d7-f1fe-4d96-aa2f-aad8a797028c
          History

          Autophagosome,Training,ROS,Mitochondrial dynamics
          Autophagosome, Training, ROS, Mitochondrial dynamics

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