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      Joint effects of gray matter atrophy and altered functional connectivity on cognitive deficits in amnestic mild cognitive impairment patients.

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          Abstract

          Gray matter (GM) atrophy and disrupted intrinsic functional connectivity (IFC) are often present in patients with amnestic mild cognitive impairment (aMCI), which shows high risk of developing into Alzheimer's disease. Little is known, however, about the relationship between GM atrophy and altered IFC, and whether they are related to cognitive decline.

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          Author and article information

          Journal
          Psychol Med
          Psychological medicine
          Cambridge University Press (CUP)
          1469-8978
          0033-2917
          Jul 2015
          : 45
          : 9
          Affiliations
          [1 ] Department of Neurology,Affiliated Zhongda Hospital of Southeast University,Nanjing,People's Republic of China.
          [2 ] Institute of Neuropsychiatry of Southeast University,Nanjing,People's Republic of China.
          [3 ] Department of Psychology,Affiliated Zhongda Hospital of Southeast University,Nanjing,People's Republic of China.
          Article
          S0033291714002876
          10.1017/S0033291714002876
          25511078
          b0997d2b-3062-4d6a-a5ac-f05af2c15338

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