+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Endothelium of Human Umbilical Blood Vessels: Ultrastructural Immunolocalization of Neuropeptides


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Endothelial cells of human umbilical vein and artery, both in situ and in culture, were examined ultrastructurally and at the light-microscope level using either the pre-embedding peroxidase-antiperoxidase or avidin-biotin peroxidase complex immunostaining techniques. Vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP) and arginine-vasopressin (AVP) immunoreactivity were localized in subpopulations of endothelial cells of the term umbilical vein and artery. The percentage of VIP-, SP-, CGRP- and AVP-immunoreactive cells in the umbilical vein was 12, 10, 11, and 7.5%, respectively, out of a total of 5,364 cells (from 15 umbilical cords) examined. The artery contained fewer VIP-, SP-, and CGRP-immunoreactive cells, but more AVP-immunoreactive cells, than the vein. In conclusion, subpopulations of endothelial cells in the human umbilical vein and artery contain the neuropeptides VIP, SP, CGRP and AVP, although their physiological roles are not yet known.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 30
          : 6
          : 348-355
          Department of Anatomy and Developmental Biology, Centre for Neuroscience, University College London, London, UK
          159017 J Vasc Res 1993;30:348–355
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Research Paper


          Comment on this article