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Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice
Derek R. Stein ,
Joseph W. Golden ,
Bryan D. Griffin ,
Bryce M. Warner ,
Charlene Ranadheera ,
Leanne Scharikow ,
Angela Sloan ,
Kathy L. Frost ,
Darwyn Kobasa ,
Stephanie A. Booth ,
Matthew Josleyn ,
John Ballantyne ,
Eddie Sullivan ,
Jin-an Jiao ,
Hua Wu ,
Zhongde Wang ,
Jay W. Hooper ,
David Safronetz
October 2017
October 2017
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Abstract
Zika virus (ZIKV) is rapidly spreading throughout the Americas and is associated with
significant fetal complications, most notably microcephaly. Treatment with polyclonal
antibodies for pregnant women at risk of ZIKV-related complications could be a safe
alternative to vaccination. We found that large quantities of human polyclonal antibodies
could be rapidly produced in transchromosomal bovines (TcB) and successfully used
to protect mice from lethal infection. Additionally, antibody treatment eliminated
ZIKV induced tissue damage in immunologically privileged sites such as the brain and
testes and protected against testicular atrophy. These data indicate that rapid development
and deployment of human polyclonal antibodies could be a viable countermeasure against
ZIKV.