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      Vasculogenesis in the day 6.5 to 9.5 mouse embryo.


      Allantois, cytology, Animals, Antigens, CD, Antigens, CD31, biosynthesis, genetics, Antigens, CD34, Aorta, embryology, metabolism, Basic Helix-Loop-Helix Transcription Factors, Cadherins, Cells, Cultured, DNA-Binding Proteins, Embryo, Mammalian, blood supply, Endocardium, Endothelium, Vascular, Fetal Heart, Gene Expression Regulation, Developmental, Gestational Age, Mesoderm, Mice, Morphogenesis, Neovascularization, Physiologic, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Receptor, TIE-2, Receptors, Growth Factor, Receptors, Vascular Endothelial Growth Factor, Transcription Factors

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          The process of vasculogenesis was characterized in the 6.5- to 9.5-day mouse embryo and in allantoic culture by analysis of spatial and temporal expression patterns of the endothelial or hematopoietic lineage-associated proteins, TAL1, Flk1, platelet/endothelial cell adhesion molecule (PECAM), CD34, VE-cadherin, and Tie2. The study establishes that: (1) TAL1 and Flk1 are coexpressed in isolated mesodermal cells that give rise to endothelial cells and thus can be defined as angioblasts; (2) hematopoietic cells of blood islands express TAL1, but not Flk1; (3) vasculogenesis in the embryo proper is initiated by mesoderm fated to give rise to the endocardium; (4) the maturation/morphogenesis of blood vessels can be defined in terms of a sequential pattern of expression in which TAL1 and Flk1 are expressed first followed by PECAM, CD34, VE-cadherin, and later Tie2; and (5) TAL1 expression is down-regulated in endothelial cells of mature vessels. (Blood. 2000;95:1671-1679)

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