Efficacy thresholds for clinical trials with advanced or metastatic leiomyosarcoma patients: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group meta-analysis based on a literature review for soft-tissue sarcomas.

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Abstract

In 2002, the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group reported well-established values for conducting phase II trials for soft-tissue sarcomas. An update is provided for leiomyosarcoma (LMS).

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Journal

Journal ID (iso-abbrev): Eur J Cancer

Title: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

ISSN (Electronic): 1879-0852

ISSN (Print): 0959-8049

Publication date (Electronic): September 2021

Volume: 154

Affiliations

[1 ] EORTC Headquarters, Brussels, Belgium.

[2 ] Division of Clinical Studies, Institute of Cancer Research, London, UK.

[3 ] Department of General Medical Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

[4 ] Gerhard Domagk Institute of Pathology, University Hospital Münster, Germany.

[5 ] Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

[6 ] Sarcoma Unit, Division of Medical Oncology, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy.

[7 ] Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

[8 ] Sarcoma Unit, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.

[9 ] Mathematical Institute Leiden University, Leiden, the Netherlands.

[10 ] Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: a.j.gelderblom@lumc.nl.

Article

Publisher Item ID: S0959-8049(21)00400-7

DOI: 10.1016/j.ejca.2021.06.025

PubMed ID: 34298376

SO-VID: b0cbaf76-5262-4165-a64f-a10300c8af96

History

Keywords: Efficacy,Benchmark,Meta-analysis,Study design,Advanced or metastatic leiomyosarcoma

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Keywords: Efficacy, Benchmark, Meta-analysis, Study design, Advanced or metastatic leiomyosarcoma

Efficacy thresholds for clinical trials with advanced or metastatic leiomyosarcoma patients: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group meta-analysis based on a literature review for soft-tissue sarcomas.

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