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      Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins.

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          Abstract

          Lung cancer is the foremost cause of cancer mortality and a growing economic burden worldwide. Rhizoma paridis saponins (RPS) have been reported to exhibit potential anti-tumor effects on many kinds of tumor models. The present study was designed to investigate the mechanism-based chemopreventive nature of RPS against DEN-induced lung carcinogenesis in Kunming mice. As a result, the treatment with RPS reduced the severity of pulmonary histopathology. The mechanism of its antitumor effect involved in (a) reducing oxidative stress injury through up-regulating activities of CAT and SOD; (b) down-regulating the levels of inflammatory factors, like TNF-α, IL6, COX-2, and PGE2; (c) activation of caspase-3 and up-regulating the pro-apoptotic protein Bax; (d) decreasing the expression of PCNA; (e) depressing the expression of cancer stem cells marker CD133; (f) suppressing aberrant expression of cytokeratin 8 and 18; and (g) inhibiting EGFR/ PI3 K/Akt, EGFR/Ras/Erk and NF-κB pathways. Taken together, RPS would be a potent agent inhibiting lung tumor in the future.

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          Author and article information

          Journal
          Mol. Carcinog.
          Molecular carcinogenesis
          Wiley-Blackwell
          1098-2744
          0899-1987
          May 2017
          : 56
          : 5
          Affiliations
          [1 ] Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering, Lab of Metabolic Control Fermentation Technology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
          [2 ] Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
          Article
          10.1002/mc.22601
          27991692
          b0d6511a-ba4a-4ef6-8070-3dfd39186c03
          History

          Rhizoma paridis saponins,apoptosis,diethylnitrosamine,inflammation,lung tumor,oxidative stress

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