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Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group
Daan van Rooij
1 ,
Evdokia Anagnostou
1 ,
Celso Arango
1 ,
Guillaume Auzias
1 ,
Marlene Behrmann
1 ,
Geraldo F. Busatto
1 ,
Sara Calderoni
1 ,
Eileen Daly
1 ,
Christine Deruelle
1 ,
Adriana Di Martino
1 ,
Ilan Dinstein
1 ,
Fabio Luis Souza Duran
1 ,
Sarah Durston
1 ,
Christine Ecker
1 ,
Damien Fair
1 ,
Jennifer Fedor
1 ,
Jackie Fitzgerald
1 ,
Christine M. Freitag
1 ,
Louise Gallagher
1 ,
Ilaria Gori
1 ,
Shlomi Haar
1 ,
Liesbeth Hoekstra
1 ,
Neda Jahanshad
1 ,
Maria Jalbrzikowski
1 ,
Joost Janssen
1 ,
Jason Lerch
1 ,
Beatriz Luna
1 ,
Mauricio Moller Martinho
1 ,
Jane McGrath
1 ,
Filippo Muratori
1 ,
Clodagh M. Murphy
1 ,
Declan G.M. Murphy
1 ,
Kirsten O’Hearn
1 ,
Bob Oranje
1 ,
Mara Parellada
1 ,
Alessandra Retico
1 ,
Pedro Rosa
1 ,
Katya Rubia
1 ,
Devon Shook
1 ,
Margot Taylor
1 ,
Paul M. Thompson
1 ,
Michela Tosetti
1 ,
Gregory L. Wallace
1 ,
Fengfeng Zhou
1 ,
Jan K. Buitelaar
1
April 2018
April 2018
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Abstract
Neuroimaging studies show structural differences in both cortical and subcortical
brain regions in children and adults with autism spectrum disorder (ASD) compared
with healthy subjects. Findings are inconsistent, however, and it is unclear how differences
develop across the lifespan. The authors investigated brain morphometry differences
between individuals with ASD and healthy subjects, cross-sectionally across the lifespan,
in a large multinational sample from the Enhancing Neuroimaging Genetics Through Meta-Analysis
(ENIGMA) ASD working group.