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      Empirical threshold values for quantitative trait mapping.

      1 ,
      Genetics
      Oxford University Press (OUP)

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          Abstract

          The detection of genes that control quantitative characters is a problem of great interest to the genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative to maps of genetic markers are now widely used. This paper addresses an issue common to all QTL mapping methods, that of determining an appropriate threshold value for declaring significant QTL effects. An empirical method is described, based on the concept of a permutation test, for estimating threshold values that are tailored to the experimental data at hand. The method is demonstrated using two real data sets derived from F(2) and recombinant inbred plant populations. An example using simulated data from a backcross design illustrates the effect of marker density on threshold values.

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          Author and article information

          Journal
          Genetics
          Genetics
          Oxford University Press (OUP)
          0016-6731
          0016-6731
          Nov 1994
          : 138
          : 3
          Affiliations
          [1 ] Biometrics Unit, Cornell University, Ithaca, New York 14853.
          Article
          10.1093/genetics/138.3.963
          1206241
          7851788
          b10ad172-63df-419b-803e-a58eb529d8f0
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