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      Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis.

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          Abstract

          Sepsis is a leading cause of mortality in noncoronary ICUs. Although immediate start of antibiotics reduces sepsis-related mortality, antibiotics are often administered for too long, leading to suboptimal treatment and, importantly, contributes to antimicrobial resistance. Prior literature suggests that procalcitonin correlates with infection and thus may help to guide the decision on when to stop antibiotic treatment. This study was conducted as part of a regulatory submission to the U.S. Food and Drug Administration and aimed to summarize the evidence of procalcitonin guidance on efficacy and safety outcomes in adult patients with sepsis.

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          Author and article information

          Journal
          Crit. Care Med.
          Critical care medicine
          Ovid Technologies (Wolters Kluwer Health)
          1530-0293
          0090-3493
          May 2018
          : 46
          : 5
          Affiliations
          [1 ] bioMérieux, Marcy-l'Étoile, France.
          [2 ] Analysis Group Inc., Boston, MA.
          [3 ] bioMérieux, Durham, NC.
          [4 ] University of California, San Diego, CA.
          [5 ] University of Basel, Switzerland.
          Article
          10.1097/CCM.0000000000002928
          29271844

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