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      Effects of Prolactin on Cultured Human Endometrial Cells


      Hormone Research in Paediatrics

      S. Karger AG

      Prolactin, Endometrium, Cell culture, Implantation, in vitro

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          We report the effects of PRL on cultured human endometrial cells (epithelial cells and stromal cells) and discuss the role of PRL in implantation. Essentially similar responses to PRL in cell attachment and growth were obtained both in epithelial and stromal cells: a low concentration of PRL (3–30 ng/ml of PRL) enhanced cell attachment and growth. In contrast, the presence of a high concentration of PRL (over 100 ng/ml) resulted in a decrease in cell attachment and growth in normal culture conditions. Morphological analysis of epithelial glandular reformation on basement membrane extracts indicated that PRL had dual effects on endometrial epithelial cells: as a stimulator in low concentrations and an inhibitor in high concentrations. These data suggest that PRL may influence the functions of human endometrial cells in a dual way depending on its level and plays an important role in the implantation process.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 35
          : Suppl 1
          : 50-57
          Department of Obstetrics and Gynecology, Fukui Medical School, Fukui, Japan
          181930 Horm Res 1991;35:50–57
          © 1991 S. Karger AG, Basel

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          Page count
          Pages: 8
          New Aspects of Prolactin in Human Reproductive Physiology


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