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[Abnormal hematopoiesis in psoriasis--in vitro studies].

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      Abstract

      Using mononuclear cells (MNC) of patients suffering from psoriasis for production of colony-stimulating factors (CSF) an abnormal colony formation in bone marrow of healthy volunteers was detected (colony-forming assay): Number of colonies per 10(5) bone marrow cells after cultivation with 10(6) MNC of patients suffering from psoriasis vulgaris: 65 +/- 14 (n = 8); psoriasis arthropathica: 63 +/- 11 (n = 8). Control values (10(5) bone marrow cells plus 10(6) MNC of healthy donors): 116 +/- 23 (n = 10). Statistical differences: psoriasis vulgaris: p less than 0.001; psoriasis arthropathica: p less than 0.001. The mechanisms responsible for these abnormalities in hematopoiesis are still unknown. They may be of pathogenic significance in psoriasis.

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      Affiliations
      [1 ] Klinik und Poliklinik für Hautkrankheiten, Humboldt-Universität zu Berlin, DDR.
      Journal
      Dermatol Monatsschr
      Dermatologische Monatschrift
      0011-9083
      0011-9083
      1990
      : 176
      : 2-3
      2365111

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