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      Overview of the CCP4 suite and current developments

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          Abstract

          An overview of the CCP4 software suite for macromolecular crystallography is given.

          Abstract

          The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of programs and associated data and software libraries which can be used for macromolecular structure determination by X-ray crystallography. The suite is designed to be flexible, allowing users a number of methods of achieving their aims. The programs are from a wide variety of sources but are connected by a common infrastructure provided by standard file formats, data objects and graphical interfaces. Structure solution by macromolecular crystallo­graphy is becoming increasingly automated and the CCP4 suite includes several automation pipelines. After giving a brief description of the evolution of CCP4 over the last 30 years, an overview of the current suite is given. While detailed descriptions are given in the accompanying articles, here it is shown how the individual programs contribute to a complete software package.

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          Author and article information

          Conference
          Acta Crystallogr D Biol Crystallogr
          Acta Cryst. D
          Acta Crystallographica Section D: Biological Crystallography
          International Union of Crystallography
          0907-4449
          1399-0047
          01 April 2011
          18 March 2011
          18 March 2011
          : 67
          : Pt 4 ( publisher-idID: d110400 )
          : 235-242
          Affiliations
          [a ]STFC Daresbury Laboratory, Daresbury, Warrington WA4 4AD, England
          [b ]STFC Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, England
          [c ]York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, England
          [d ]Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
          [e ]MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England
          [f ]University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, England
          [g ]Biophysical Structural Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
          Author notes
          Correspondence e-mail: martyn.winn@ 123456stfc.ac.uk
          Article
          dz5219 ABCRE6 S0907444910045749
          10.1107/S0907444910045749
          3069738
          21460441
          b14fc97d-0664-4d84-8e05-383459f93418
          © Winn et al. 2011

          This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

          Proceedings of the CCP4 study weekend
          Categories
          Research Papers

          Microscopy & Imaging
          ccp4,macromolecular crystallography,software,collaboration,automation,macromolecular structure determination

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