Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
13
July
2016
Publication date Collection: 2016
Volume: 11
Issue: 7
Electronic Location Identifier: e0159276
Affiliations
[1
]McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of
Medicine, Texas Children’s Hospital, Houston, Texas, United States of America
[2
]Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University,
Cambridge, Massachusetts, United States of America
[3
]Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States
of America
University of British Columbia, CANADA
Author notes
Competing Interests: JAK has served on the scientific advisory board of Johnson & Johnson and currently
serves on an advisory board for Lexicon. This does not alter the authors' adherence
to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: ARC OB EPC CJL PY DAM JAK. Performed the experiments:
ARC OB EPC JSR JC CWB CJL PY. Analyzed the data: ARC OB EPC JSR JC CWB CJL PY DAM
JAK. Contributed reagents/materials/analysis tools: EPC PY. Wrote the paper: ARC OB
EPC PY DAM JAK.
Author information
Article
Publisher ID:
PONE-D-16-18943
DOI: 10.1371/journal.pone.0159276
PMC ID: 4943640
PubMed ID: 27410263
SO-VID: b16441e5-26f1-4074-a509-10caf65fc872
Copyright © © 2016 Cox et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: National Institutes of Health (US)
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3646-1744
Jake A Kushner
Funded by: Harvard Stem Cell Institute (US)
Award Recipient
:
Doug A Melton
Funded by: Robert and Janice McNair Foundation (US)
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3646-1744
Jake A Kushner
Funded by: Diabetes Research Center of the Baylor College of Medicine
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3646-1744
Jake A Kushner
Funded by: Howard Hughes Medical Institute (US)
Award Recipient
:
Doug A Melton
This work was supported by the National Institutes of Health (NIH NIA - 1R01AG04101)
(
www.nia.nih.gov), the Howard Hughes Medical Institute (HHMI) (
www.hhmi.org), the Harvard Stem Cell Institute (hsci.harvard.edu), the Robert and Janice McNair
Foundation (
www.mcnairfoundation.org) and the Diabetes Research Center at Baylor College of Medicine (
www.bcm.edu/research/centers/diabetes-research/). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Proliferation
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Recombinant Proteins
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Endocrine System
Subject:
Pancreas
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Endocrine System
Subject:
Pancreas
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Exocrine Glands
Subject:
Pancreas
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Exocrine Glands
Subject:
Pancreas
Subject:
Research and Analysis Methods
Subject:
Cell Enumeration Techniques
Subject:
Total Cell Counting
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Serum Triglycerides
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Serum Triglycerides
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Serum Triglycerides
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Serum Triglycerides
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Blood
Subject:
Blood Serum
Subject:
Serum Triglycerides
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Immune Serum
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Immune Serum
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Immune Serum
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Serum
Subject:
Immune Serum
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Blood
Subject:
Blood Serum
Subject:
Immune Serum
Subject:
Research and Analysis Methods
Subject:
Specimen Preparation and Treatment
Subject:
Staining
Subject:
Immunostaining