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Defining hormesis: comments on Calabrese and Baldwin (2002).

Human & Experimental Toxicology

Risk Assessment, radiation effects, drug effects, Receptors, Drug, No-Observed-Adverse-Effect Level, etiology, Neoplasms, Humans, physiology, Homeostasis, Dose-Response Relationship, Radiation, Dose-Response Relationship, Drug, Chromosome Aberrations, Biological Evolution, Adaptation, Physiological

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      Abstract

      The definition of hormesis should not include non-scientific judgments as to beneficial or harmful effects. Evaluating the significance of hormesis is a separate issue that ultimately requires risk:risk comparisons, particularly since the evolutionary basis for hormesis appears to be Lamarkian rather than Darwinian. It is arguable whether 'hormesis' is the correct umbrella term for all low-dose exposure responses, in particular those at higher organization levels than single species, or whether it includes arousal responses.

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      12102504

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