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      Usefulness of Urinary Growth Hormone (GH) Measurement for Evaluating Endogenous GH Secretion in Acromegaly

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          We investigated the relationship between urinary growth hormone (u-GH) and spontaneous 24-hour plasma GH secretion in 15 acromegalic patients. To measure u-GH, we have developed a method based on concentrating the sample by centrifugal ultraflltration and then performing an immunoradiometric assay using commercially available reagents. u-GH correlated well with the integrated concentration of plasma GH (r = 0.66, p < 0.02). Additionally, u-GH excretion in acromegalic patients was significantly higher than in the control group (190 ± 100 vs. 3.89 ± 0.56 pg/min, mean ± SEM, p < 0.001). Immunoreactive u-GH showed the same elution pattern in Sephadex G-75 as standard or labeled hGH, proving that the substance measured in urine is authentic GH. In conclusion, u-GH appears to be a simple, noninvasive and inexpensive test for evaluating GH secretion in active acromegaly.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 39
          : 1-2
          : 13-18
          aLaboratorio de Hormonas, y bSección de Endocrinología, Hospital General d’Alacant, Alicante, Espana
          182688 Horm Res 1993;39:13–18
          © 1993 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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