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      Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention.

      Journal of Controlled Release
      Administration, Oral, Chemistry, Pharmaceutical, Drug Delivery Systems, Gastric Emptying, Humans, Pharmacokinetics, Stomach, metabolism

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          Abstract

          In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

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          Author and article information

          Journal
          10601721
          10.1016/S0168-3659(99)00204-7

          Chemistry
          Administration, Oral,Chemistry, Pharmaceutical,Drug Delivery Systems,Gastric Emptying,Humans,Pharmacokinetics,Stomach,metabolism

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