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      Diabetic neuropathy: mechanisms to management.

      Pharmacology & Therapeutics

      therapeutic use, Hypoglycemic Agents, Diabetic Nephropathies, Humans, pathology, metabolism, diagnosis, epidemiology, drug therapy, Analgesics, drug effects, Signal Transduction, Blood Glucose

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          Abstract

          Neuropathy is the most common and debilitating complication of diabetes and results in pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of forms whose impact ranges from discomfort to death. Hyperglycemia induces oxidative stress in diabetic neurons and results in activation of multiple biochemical pathways. These activated pathways are a major source of damage and are potential therapeutic targets in diabetic neuropathy. Though therapies are available to alleviate the symptoms of diabetic neuropathy, few options are available to eliminate the root causes. The immense physical, psychological, and economic cost of diabetic neuropathy underscore the need for causally targeted therapies. This review covers the pathology, epidemiology, biochemical pathways, and prevention of diabetic neuropathy, as well as discusses current symptomatic and causal therapies and novel approaches to identify therapeutic targets.

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          Author and article information

          Journal
          18616962
          4007052
          10.1016/j.pharmthera.2008.05.005

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