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      Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model.

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          Abstract

          Activation of the farnesoid X receptor (FXR), a member of the nuclear receptor steroid superfamily, leads to anti-inflammatory and anti-fibrotic effects in several tissues, including the lung. We have recently demonstrated a protective effect of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) in rat models of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) and bleomycin-induced pulmonary fibrosis. The aim of the present study was to investigate whether the positive effects of OCA treatment could be exerted also in established MCT-induced PAH, i.e., starting treatment 2 weeks after MCT administration.

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          Author and article information

          Journal
          J Endocrinol Invest
          Journal of endocrinological investigation
          Springer Science and Business Media LLC
          1720-8386
          0391-4097
          Aug 2019
          : 42
          : 8
          Affiliations
          [1 ] Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, AOU Careggi, Viale Pieraccini, 6, 50139, Florence, Italy.
          [2 ] Interdepartmental Laboratory of Functional and Cellular Pharmacology of Reproduction, Department of NEUROFARBA, University of Florence, Florence, Italy.
          [3 ] Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
          [4 ] Intercept Pharmaceuticals, New York, NY, USA.
          [5 ] I.N.B.B. (Istituto Nazionale Biostrutture E Biosistemi), Rome, Italy.
          [6 ] Sexual Medicine and Andrology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, AOU Careggi, Viale Pieraccini, 6, 50139, Florence, Italy. linda.vignozzi@unifi.it.
          [7 ] I.N.B.B. (Istituto Nazionale Biostrutture E Biosistemi), Rome, Italy. linda.vignozzi@unifi.it.
          Article
          10.1007/s40618-019-1009-2
          10.1007/s40618-019-1009-2
          30674010
          b1928a0e-6ae9-46f2-b7b4-950a1450e65c
          History

          Farnesoid X receptor,Inflammation,Monocrotaline,Obeticholic acid,Pulmonary hypertension

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