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      Augmented Renal Clearance in Critically Ill Patients: A Systematic Review

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          Abstract

          Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context. Nevertheless, augmented renal clearance (ARC) is a less well-studied phenomenon that could lead to faster elimination of drugs, resulting in subtherapeutic concentrations and poorer clinical outcomes when standard dosage guidelines are followed.

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          Author and article information

          Journal
          Clinical Pharmacokinetics
          Clin Pharmacokinet
          Springer Science and Business Media LLC
          0312-5963
          1179-1926
          September 2018
          February 13 2018
          September 2018
          : 57
          : 9
          : 1107-1121
          Article
          10.1007/s40262-018-0636-7
          29441476
          b19efa73-d587-49de-970f-a08813b01fc6
          © 2018

          http://www.springer.com/tdm

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