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      Therapeutics and Clinical Risk Management (submit here)

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      Is Open Access

      Surveillance of antibiotic and analgesic use in the Oral Surgery Department of the University Dentistry Clinical Center of Kosovo

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          Abstract

          Background

          Because Kosovo has no reliable information on antimicrobial and analgesic use in dental practice, the survey reported here evaluated the antibiotic and analgesic prescriptions in the Oral Surgery Department of the University Dentistry Clinical Center of Kosovo (UDCCK).

          Methods

          The data of 2,442 registered patients for a 1-year period were screened and analyzed concerning antibiotic and analgesic use as per standards of rational prescription.

          Results

          Dentistry doctors prescribed antibiotics significantly more often than analgesics. Antibiotics were prescribed in 8.11% of all cases, while only 1.35% of total prescriptions were for analgesics. The total consumption of antibiotic drugs in the UDCCK was 4.53 Defined Daily Doses [DDD]/1,000 inhabitants/day, compared with only 0.216 DDD/1,000 inhabitants/day for analgesics. From a total number of 117 patients, 32 patients received combinations of two antibiotics.

          Conclusion

          Pharmacotherapy analysis showed that the prescription rates of antibiotics and analgesics in the UDCCK are not rational in terms of the qualitative aspects of treatment. For the qualitative improvement of prescription of these drug groups, we recommend the implementation of treatment guidelines following rational standards.

          Most cited references26

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          Antimicrobial resistance — A ticking bomb!

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            Antibiotic consumption and link to resistance.

            Antibiotic use in the treatment of respiratory tract infections is common in primary care. The European Surveillance of Antimicrobial Consumption (ESAC programme), collecting data from 35 countries, showed that antibiotic use was highest in southern European countries. Increased antibiotic consumption has been shown by numerous ecological studies to contribute to the emergence of antibiotic resistance in streptococci. A study comparing outpatient antibiotic consumption in the USA showed it to be similar to that in southern European countries, but macrolides, particularly azithromycin, are among the first-line agents prescribed in the USA for respiratory infections. In Europe, patients are more likely to receive a beta-lactam; and when a macrolide is indicated, clarithromycin is more likely to be prescribed than azithromycin. Streptococci resistance to macrolides can be acquired via two mechanisms: by the mef gene, which encodes for the efflux pump mechanism, producing low to moderate resistance, or the erm gene (post-transcriptional modification of the bacterial ribosomal unit), resulting in high resistance. Macrolide resistance is mediated by erm(B) and mef(A) alone or in combination. A surveillance study showed that mef was responsible for most of the macrolide resistance seen in the USA; a decrease in the number of isolates carrying mef(A) was associated with a doubling of the number of isolates carrying both mef(A) and erm(B). Higher consumption of clarithromycin in Europe correlated with a predominance of erm(B)-carrying Streptococcus pneumoniae. The erm(B) gene caused resistance in 84% of the isolates in Europe.
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              Orthodontic pain: from causes to management--a review.

              Orthodontic pain, the most cited negative effect arising from orthodontic force application, is a major concern for parents, patients, and clinicians. Studies have reported this reaction to be a major deterrent to orthodontic treatment and an important reason for discontinuing treatment. Surprisingly this area, which requires attention in clinical practice as well as in research, is ignored as evidenced by the scarcity of publications on the topic in comparison with other areas of orthodontic research. This review attempts to organize the existing published literature regarding pain, which appears as part of orthodontic mechanotherapy and to address questions that might arise in a clinical setting from the viewpoint of clinicians and patients/parents. It also provides an overview of current management strategies employed for alleviating orthodontic pain.
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                Author and article information

                Journal
                Ther Clin Risk Manag
                Ther Clin Risk Manag
                Therapeutics and Clinical Risk Management
                Therapeutics and Clinical Risk Management
                Dove Medical Press
                1176-6336
                1178-203X
                2015
                01 October 2015
                : 11
                : 1497-1503
                Affiliations
                [1 ]Department of Forensic Medicine, Faculty of Medicine, University of Prishtina “Hasan Prishtina”, Prishtina, Kosovo
                [2 ]Department of Children Dentistry, University Dentistry Clinical Center of Kosovo, Prishtina, Kosovo
                [3 ]Department of Oral Disease, University Dentistry Clinical Center of Kosovo, Prishtina, Kosovo
                [4 ]Department of Oral Surgery, University Dentistry Clinical Center of Kosovo, Prishtina, Kosovo
                [5 ]Institute of Pharmacology and Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Prishtina “Hasan Prishtina”, Prishtina, Kosovo
                Author notes
                Correspondence: Shaip L Krasniqi, Institute of Pharmacology and Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Prishtina “Hasan Prishtina”, “Mother Teresa” Street Rrethi i Spitaleve pn, 10000 Prishtina, Kosovo, Tel +381 38 500 600 2012, Email shaip.krasniqi@ 123456uni-pr.edu
                Article
                tcrm-11-1497
                10.2147/TCRM.S87595
                4599059
                26491336
                b1a502da-0927-4527-a1f1-d39f179661cf
                © 2015 Haliti et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

                The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Original Research

                Medicine
                antibiotic,analgesics,anatomic therapeutic classification,ddd/1,000 inhabitants/day,rational standards

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