1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Physiological functions of APP family proteins.

      1 ,
      Cold Spring Harbor perspectives in medicine
      Cold Spring Harbor Laboratory

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Biochemical and genetic evidence establishes a central role of the amyloid precursor protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β-amyloid (Aβ) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of familial AD (FAD) and cerebral amyloid angiopathy. As such, the biological functions of APP and its processing products have been the subject of intense investigation, and the past 20+ years of research have met with both excitement and challenges. This article will review the current understanding of the physiological functions of APP in the context of APP family members.

          Related collections

          Author and article information

          Journal
          Cold Spring Harb Perspect Med
          Cold Spring Harbor perspectives in medicine
          Cold Spring Harbor Laboratory
          2157-1422
          2157-1422
          Feb 2012
          : 2
          : 2
          Affiliations
          [1 ] Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, D-69120 Heidelberg, Germany. u.mueller@urz.uni-hd.de
          Article
          a006288
          10.1101/cshperspect.a006288
          3281588
          22355794
          b1aa09da-011e-4c26-b547-fafad7c361e9
          History

          Comments

          Comment on this article