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      Inhibition of Ovulation Induced with PMS and HCG by a Melatonin-Free Extract of Bovine Pineal Powder

      research-article
      , ,
      Neuroendocrinology
      S. Karger AG
      Pineal, Antigonadotropin, Ovulation inhibitor

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          Abstract

          Using borate buffer a substance that suppresses the ovulation induced with PMS and HCG in immature mice was obtained from acetone-defatted bovine pineal powder by an extraction method similar to that used for an extraction of a gonadotropin-inhibiting substance in urine. This gonadotropin inhibitor in the pineal powder differs from melatonin or arginine vasotocin and seems to be different from the water soluble antigonadotropic substance which has been isolated from the bovine and ovine pineal. Partial purification of the gonadotropin inhibitor was accomplished by a Sephadex G-100 column.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1975
          1975
          20 March 2008
          : 18
          : 4
          : 311-321
          Affiliations
          Department of Biochemistry, Iwate Medical University School of Medicine, Morioka, Iwate
          Article
          122412 Neuroendocrinology 1975;18:311–321
          10.1159/000122412
          1214962
          b1d63c1e-c658-4021-8af0-793fb4ebfd8e
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 13 March 1975
          : 22 June 1975
          Page count
          Pages: 11
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Antigonadotropin,Pineal,Ovulation inhibitor

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