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      Cerebral tissue water spin-spin relaxation times in human neonates at 2.4 Tesla: Methodology and the effects of maturation

      , , , , ,
      Magnetic Resonance Imaging
      Elsevier BV

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          Abstract

          Using a 4-echo spin-echo sequence, cerebral T2 was measured in specific anatomic regions in eleven healthy newborn infants, whose gestational plus postnatal ages (GPAs) lay between 37 and 42 weeks. For a region in the pons, T2 was 141+/-9 ms (mean +/- standard deviation), and no significant dependence upon GPA was seen. In the thalamus mean T2 was 136+/-13 ms, and T2 demonstrated a significant negative linear dependence upon age (r = 0.690; p < 0.02). In periventricular and frontal regions, mean T2 were 217+/-33, and 228+/-32 ms respectively, and more marked negative linear correlations with age were observed (r = 0.833; p < 0.001 and r = 0.722; p < 0.02). For these regions, the rate of T2 decrease with age appeared to be related to known patterns of myelination. For the parietal region studied, mean T2 was 204+/-34 ms, no significant dependence upon GPA being seen. T2 shows promise as an objective measure of cerebral development in the perinatal period.

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          Author and article information

          Journal
          Magnetic Resonance Imaging
          Magnetic Resonance Imaging
          Elsevier BV
          0730725X
          November 1999
          November 1999
          : 17
          : 9
          : 1289-1295
          Article
          10.1016/S0730-725X(99)00063-6
          10576714
          b1e6c6f7-59de-4ca5-8a65-ffb06ed2db17
          © 1999

          https://www.elsevier.com/tdm/userlicense/1.0/

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