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      A Cluster of Cholinergic Premotor Interneurons Modulates Mouse Locomotor Activity

      , , , , ,
      Neuron
      Elsevier BV

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          Abstract

          Mammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive prominent "C bouton" cholinergic inputs from spinal interneurons, but the source and function of these synaptic inputs have remained obscure. We show here that the transcription factor Pitx2 marks a small cluster of spinal cholinergic interneurons, V0(C) neurons, that represents the sole source of C bouton inputs to motor neurons. The activity of these cholinergic interneurons is tightly phase locked with motor neuron bursting during fictive locomotor activity, suggesting a role in the modulation of motor neuron firing frequency. Genetic inactivation of the output of these neurons impairs a locomotor task-dependent increase in motor neuron firing and muscle activation. Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          08966273
          December 2009
          December 2009
          : 64
          : 5
          : 645-662
          Article
          10.1016/j.neuron.2009.10.017
          2891428
          20005822
          b209bfbd-d9c1-4105-b06a-10bf3183486f
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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