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      Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance.

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          Abstract

          Oxaliplatin is a widely used anti-advanced colorectal cancer drug, while it could induce neuropathy. Houttuynia cordata Thunb (HCT) has a wide range of biological activities, such as anti-inflammation, anti-cancer, and immune regulation. In the present study, we investigated the effect of HCT on oxaliplatin-induced neuropathy in rat models. HCT (1000 mg/kg/day) significantly decreased the number of withdrawal responses and the withdrawal latency in oxaliplatin-treated rats. HCT could down-regulated the serum levels of Interleukin-6 (IL-6) and macrophage inflammatory protein1-α (MIP-1α) in oxaliplatin-treated rats. Th17/Treg balance was reversed by HCT in oxaliplatin-treated rats by regulating PI3K/Akt/mTOR signaling pathway. The present results suggest that HCT is useful as a therapeutic drug for oxaliplatin-induced neuropathic pain.

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          Author and article information

          Journal
          Am J Transl Res
          American journal of translational research
          1943-8141
          2016
          : 8
          : 3
          Affiliations
          [1 ] Department of Anesthesiology, The First Hospital of China Medical University Shenyang City, Liaoning Province, P. R. China.
          [2 ] Department of Endocrinology, The 4th Affiliated Hospital of China Medical University Shenyang City, P. R. China.
          Article
          4859645
          27186286
          b223cc19-afe3-448f-99b1-2469f38d2f15
          History

          Oxaliplatin,neuropathic pain,Th17/Treg,PI3K/Akt/mTOR,Houttuynia cordata Thunb

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